[Fundamental studies and clinical evaluation of PC-904 in urinary tract infection (author's transl)].

Abstract

Measurement of MICs of PC-904, CBPC and GM against 135 strains of Pseudomonas aeruginosa isolated from patients with urinary tract infections was performed. Susceptibility to PC-904 of Pseudomonas aeruginosa was found to be 3 approximately 7 times more sensitive than that to CBPC and as same as that to GM with inoculum size of 10(8)/ml and 10(6)/ml. Serum level of PC-904 reached a peak of 38.5 microgram/ml 15 minutes after 0.5 g intravenous administration. Urinary recovery rate unit 6 hours after the administration was 12.5%. Overall clinical efficacy of 6 cases of acute simple cystitis and 3 cases of chronic complicated cystitis was judged to be 83.3% and 33.3% respectively by a criterion proposed by the UTI Committee in Japan.

• Authors: T Kawabata, T Goto, Y Maeyama, Y Ohi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 32 Issue 3 Pg. 306-11 (Mar 1979) ISSN: 0368-2781 [Print] Japan
• PMID: 108428 (Publication Type: Journal Article)

Chemical References

• Naphthyridines
• apalcillin
• Ampicillin

Topics

• Adult
• Aged
• Ampicillin (analogs & derivatives, metabolism, pharmacology, therapeutic use)
• Cystitis (drug therapy, microbiology)
• Drug Evaluation
• Female
• Humans
• Middle Aged
• Naphthyridines (metabolism, pharmacology, therapeutic use)
• Penicillin Resistance
• Pseudomonas aeruginosa (drug effects)