Evaluation of 60%
solution of
Methylglucamine iocarmate (
Dimer-X) for ventriculography in animal experiment and clinical cases was reported. The experimental result was compared with that of
Conray 60 and
Angiografin, which was reported in our previous papers. In seven
intraventricular injections of 2.0 ml, administered to 6 dogs, convulsion was observed on three occasions, facial
myoclonus on 1 and no symptoms on the remaining three. However, in 7
intraventricular injections of 1.5 ml for 6 dogs, 6 were symptom-free and only residual one showed convulsion. And no dog died in either experiment. No changes were seen in a subsequent ventriculogram one month after the 1st ventriculography with
Dimer-X and also no histological changes of the ventricular wall were revealed one month after the first experiment. These experimental results suggested less toxicity of
Dimer-X than
Conray 60 or
Angiografin. Clinically, in 17 neurosurgical patients, ventriculography was performed with 1-5 ml of
Dimer-X. No patients showed convulsive complication, but there was one episode of
vomiting in each of 2 cases and slight
headache in one case. From our experimental and clinical studies, it is concluded that the
Dimer-X is to be considered the best watersoluble contrast medium for ventriculography at present.