A randomized trial of intravaginal nonoxynol 9 versus oral metronidazole in the treatment of vaginal trichomoniasis.

Abstract

OBJECTIVE:

This study was undertaken to investigate the efficacy of nonoxynol 9 suppositories in the treatment of vaginal trichomoniasis.

STUDY DESIGN:

In this prospective comparison trial 46 women with documented motile trichomonads found on a wet preparation were randomly assigned to one of two treatment arms: (1) a single oral dose of 2 g metronidazole and (2) a single 150-mg nonoxynol 9 suppository placed intravaginally for 3 consecutive nights. Cure was determined by a repeated wet preparation examination. After its first year, the study was terminated because of the poor efficacy of the nonoxynol 9 suppositories.

RESULTS:

Results were available for 33 patients. Three of 17 patients treated with nonoxynol 9 had negative wet preparation results at retest (17.6% cure rate). All 16 patients treated with metronidazole had negative wet preparation results (100% cure rate). All women with nonoxynol 9 failures who were evaluated after treatment with 2 g metronidazole had negative wet preparation results.

CONCLUSION:

Intravaginal nonoxynol 9 at the tested dose and by the tested method of delivery was not an effective cure for vaginal trichomoniasis.

• Authors: N M Antonelli, S J Diehl, J W Wright
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 182 Issue 5 Pg. 1008-10 (May 2000) ISSN: 0002-9378 [Print] United States
• PMID: 10819810 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antitrichomonal Agents
• Metronidazole
• Nonoxynol

Topics

• Administration, Intravaginal
• Adolescent
• Adult
• Animals
• Antitrichomonal Agents (administration & dosage, therapeutic use)
• Female
• Humans
• Metronidazole (administration & dosage, therapeutic use)
• Middle Aged
• Nonoxynol (administration & dosage, therapeutic use)
• Prospective Studies
• Treatment Outcome
• Trichomonas Vaginitis (drug therapy, parasitology)
• Trichomonas vaginalis (isolation & purification)