Abstract | BACKGROUND: METHODS AND RESULTS: In the Canadian Implantable Defibrillator Study (CIDS), 659 patients with resuscitated ventricular tachyarrhythmias were randomly assigned to receive an ICD or amiodarone and were then followed for a mean of 3 years. There were 98 and 83 deaths in the amiodarone and ICD groups, respectively. We used multivariate Cox analysis to assess the impact of baseline parameters on the mortality in the amiodarone group. Reduced left ventricular ejection fraction, advanced age, and poor NYHA status identified high-risk patients (P=0.0001 to 0.0009). Quartiles of risk were constructed, and the mortality reduction associated with ICD treatment in each quartile was assessed. There was a significant interaction between risk quartile and the ICD treatment effect (P=0.011). In the highest risk quartile, there was a 50% relative risk reduction (95% CI 21% to 68%) of death in the ICD group, whereas in the 3 lower quartiles, there was no benefit. Patients who are most likely to benefit from an ICD can be identified with a simple risk score (>/=2 of the following factors: age >/=70 years, left ventricular ejection fraction </=35%, and NYHA class III or IV). Thirteen of 15 deaths that were prevented by the ICD occurred in patients with >/=2 risk factors. CONCLUSIONS: In CIDS, patients at highest risk of death benefited most from ICD therapy. These can be identified easily on the basis of age, poor ventricular function, and poor functional status.
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Authors | R Sheldon, S Connolly, A Krahn, R Roberts, M Gent, M Gardner |
Journal | Circulation
(Circulation)
Vol. 101
Issue 14
Pg. 1660-4
(Apr 11 2000)
ISSN: 1524-4539 [Electronic] United States |
PMID | 10758047
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Aged
- Amiodarone
(therapeutic use)
- Arrhythmias, Cardiac
(drug therapy, mortality, surgery)
- Defibrillators, Implantable
- Female
- Forecasting
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Personnel Selection
- Risk Factors
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