Current use and questions concerning intravesical bladder cancer group for superficial bladder cancer.

Abstract

Bacille Calmette-Guerin (BCG) is the most effective therapy for CIS of the bladder. Although several series have shown a decrease in recurrence and progression of T1 tumor, this effect is temporary. More than one half of patients with T1 tumors treated with BCG will progress over the longterm. A second course of BCG is indicated after an initial complete response. There is no definitive answer regarding the efficacy of maintenance therapy or the optimum dose of BCG. Randomized trials are needed to address these issues in a more conclusive manner. Phase III trials have shown that mitomycin C can be as effective as BCG in the management of papillary tumors; however, BCG is more effective in patients with CIS and high-risk superficial tumors.

• Authors: G Dalbagni, H W Herr
• Journal: The Urologic clinics of North America (Urol Clin North Am) Vol. 27 Issue 1 Pg. 137-46, (Feb 2000) ISSN: 0094-0143 [Print] United States
• PMID: 10696252 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• BCG Vaccine
• Biomarkers, Tumor
• Cancer Vaccines

Topics

• Administration, Intravesical
• Antineoplastic Agents (administration & dosage)
• BCG Vaccine (administration & dosage)
• Biomarkers, Tumor (metabolism)
• Cancer Vaccines (administration & dosage)
• Carcinoma in Situ (drug therapy, metabolism, prevention & control)
• Disease Progression
• Drug Administration Schedule
• Humans
• Neoplasm Recurrence, Local (prevention & control)
• Remission Induction
• Urinary Bladder Neoplasms (drug therapy, metabolism, prevention & control)