Clinical assessment of vascular thrombosis using indium-111 platelet scintigraphy.

Abstract	The authors reviewed the clinical value of platelet scintigraphy by using autologous platelets labeled with indium-111-oxine to detect thrombotic activity at vascular thrombosis sites. Thirty-nine patients with deep vein thrombosis, 28 with arteriosclerosis obliterans, and 10 with pulmonary embolism were the subjects of this study. Platelet accumulation on scintigrams had a tendency to correlate with aggravation of acute thrombotic symptoms in deep vein thrombosis and arteriosclerosis obliterans. In addition, appropriate thrombolytic and anticoagulant therapy resulted in reduced platelet accumulation in conjunction with improvement of acute symptoms. On the other hand, this type of scintigraphy was not so sensitive for assessment of pulmonary embolism. Platelet scintigraphy could facilitate the assessment of thrombotic activity and might be useful for determining the optimal indication of thrombolytic and anticoagulant therapy for acute vascular thrombosis.
Authors	Y Morimoto, T Sugimoto, M Okada, T Mukai
Journal	Angiology (Angiology) Vol. 51 Issue 1 Pg. 61-8 (Jan 2000) ISSN: 0003-3197 [Print] United States
PMID	10667644 (Publication Type: Journal Article)
Chemical References	Anticoagulants Fibrinolytic Agents Indium Radioisotopes Organometallic Compounds Platelet Aggregation Inhibitors Radiopharmaceuticals Technetium Tc 99m Aggregated Albumin Vasodilator Agents indium oxine Warfarin Oxyquinoline Epoprostenol Aspirin
Topics	Adult Aged Aged, 80 and over Anticoagulants (therapeutic use) Arteriosclerosis Obliterans (diagnostic imaging, drug therapy) Aspirin (therapeutic use) Blood Platelets Epoprostenol (therapeutic use) Female Fibrinolytic Agents (therapeutic use) Humans Indium Radioisotopes Male Middle Aged Organometallic Compounds Oxyquinoline (analogs & derivatives) Platelet Aggregation Inhibitors (therapeutic use) Pulmonary Embolism (diagnostic imaging, drug therapy) Radionuclide Imaging Radiopharmaceuticals Technetium Tc 99m Aggregated Albumin Vasodilator Agents (therapeutic use) Venous Thrombosis (diagnostic imaging, drug therapy) Warfarin (therapeutic use)

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