[Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker].

Abstract

59 patients with mild and moderate essential hypertension have received a course treatment with beta-adrenoblocker proxodolol. The latter was studied for a hypotensive action and cardiohemodynamic effects as regards baseline type of circulation and pacing regimen. Proxodolol hypotensive action in hyperkinetic circulation is attributed primarily to a fall in the ejection (beta-adrenoblock), in hypo- and eukinetic circulation type--to reduction in cardiac postload (alpha-adrenoblock). In isolated ventricular stimulation proxodolol cardiodepressive effect was more pronounced than in atrial stimulation. An overall hypotensive effect of proxodolol in mild arterial hypertension made up 77.2%, in moderate--66.5%.

• Authors: B G Iskenderov, I P Tatarchenko, V A Shevyrev
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 77 Issue 4 Pg. 29-31 ( 1999) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Kardiohemodinamicheskie éffekty otechestvennogo beta-adrenoblokatora proksodolola pri gipertonicheskoĭ bolezni u bol'nykh s iskusstvennym voditelem ritma serdtsa.
• PMID: 10356914 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Oxadiazoles
• proxodolol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Echocardiography
• Electrocardiography
• Female
• Follow-Up Studies
• Hemodynamics (drug effects)
• Humans
• Hypertension (diagnostic imaging, physiopathology, therapy)
• Male
• Middle Aged
• Oxadiazoles (therapeutic use)
• Pacemaker, Artificial
• Treatment Outcome