Abstract |
Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.
|
Authors | D C Hood, V Greenstein, L Frishman, K Holopigian, S Viswanathan, W Seiple, J Ahmed, J G Robson |
Journal | Vision research
(Vision Res)
Vol. 39
Issue 13
Pg. 2285-91
(Jun 1999)
ISSN: 0042-6989 [Print] England |
PMID | 10343810
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Tetrodotoxin
- N-Methylaspartate
|
Topics |
- Adult
- Animals
- Diabetic Retinopathy
(physiopathology)
- Electroretinography
(drug effects)
- Glaucoma, Open-Angle
(physiopathology)
- Humans
- Macaca mulatta
- Middle Aged
- N-Methylaspartate
(pharmacology)
- Pattern Recognition, Visual
(physiology)
- Retina
(physiology, physiopathology)
- Retinal Ganglion Cells
(physiology)
- Tetrodotoxin
(pharmacology)
|