Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion.

Abstract

AIM:

To study the effect of melatonin on hydroxyl radical (.OH) contents during cerebral ischemia-reperfusion in rats.

METHODS:

Ischemia was induced by occluding left lateral middle cerebral artery for 30 min following reperfusion. The salicylate trapping method coupled with ipsilateral striatal microdialysis for measurement of hydroxyl radicals generated during ischemia and reperfusion.

RESULTS:

The contents of dihydroxybenzoic acid (DHBA) were increased at 15 min after ischemia and remained high for 30 min after reperfusion. Melatonin (4 mg.kg-1, sc, 30 min before ischemia) decreased the production of DHBA during ischemia for 16-30 min and reperfusion for 1-30 min.

CONCLUSION:

Melatonin inhibits the production of hydroxyl radicals in rat brain during ischemia and reperfusion.

• Authors: X J Li, L M Zhang, J Gu, A Z Zhang, F Y Sun
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 18 Issue 5 Pg. 394-6 (Sep 1997) ISSN: 0253-9756 [Print] China
• PMID: 10322924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Free Radical Scavengers
• Gentisates
• Hydroxyl Radical
• Melatonin

Topics

• Animals
• Brain Ischemia (metabolism)
• Free Radical Scavengers (pharmacology)
• Gentisates (metabolism)
• Hydroxyl Radical (metabolism)
• Male
• Melatonin (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (metabolism)