Pros and cons of the use of antihistamines in managing allergic rhinitis.

Abstract

Histamine H1 -receptor antagonists are generally considered first-line therapy for the management of allergic rhinitis. Other than histamine antagonism, several of the second-generation antihistamines have also shown inhibitory effects on chemical mediators of inflammation such as leukotrienes, prostaglandins, and kinins. This article reviews the pharmacology, clinical use, and side effect profiles of the commonly used H1 -receptor antagonists.

• Authors: J Day
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 103 Issue 3 Pt 2 Pg. S395-9 (Mar 1999) ISSN: 0091-6749 [Print] United States
• PMID: 10069900 (Publication Type: Journal Article, Review)

Chemical References

• Histamine H1 Antagonists

Topics

• Histamine H1 Antagonists (adverse effects, therapeutic use)
• Humans
• Rhinitis, Allergic, Perennial (drug therapy)
• Rhinitis, Allergic, Seasonal (drug therapy)