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3- (4- chlorophenyl)- 1,4,5,6,7,8- hexahydro- 1- (phenylmethyl)pyrazolo(3,4- d)azepine 2-hydroxy-1,2,3-propanetricarboxylate

a 5-HT7 antagonist

Also Known As:

JNJ-18038683

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)pyrazolo(3,4-d)azepine 2-hydroxy-1,2,3-propanetricarboxylate: 1
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Tricarboxylic Acids: 423
      - 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)pyrazolo(3,4-d)azepine 2-hydroxy-1,2,3-propanetricarboxylate: 1

Experts

1.	Ahnaou, Abdellah: 1 article (08/2012)
2.	Aluisio, Leah: 1 article (08/2012)
3.	Bertelsen, Kirk: 1 article (08/2012)
4.	Bonaventure, Pascal: 1 article (08/2012)
5.	Carruthers, Nicholas: 1 article (08/2012)
6.	Chai, Wenying: 1 article (08/2012)
7.	De Boer, Peter: 1 article (08/2012)
8.	Di, Jianing: 1 article (08/2012)
9.	Drinkenburg, Wilhelmus: 1 article (08/2012)
10.	Dugovic, Christine: 1 article (08/2012)

Related Diseases

1.

Major Depressive Disorder (Major Depressive Disorders)

08/01/2012 - "In a double-blind, active, and placebo-controlled clinical trial in 225 patients suffering from major depressive disorder, neither treatment with pharmacologically active doses of JNJ-18038683 or escitalopram separated from placebo, indicating a failed study lacking assay sensitivity. "
08/01/2012 - "Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder."

Related Drugs and Biologics

1.	Escitalopram
2.	Serotonin (5 Hydroxytryptamine)