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TX-2098

a hypoxic cytotoxin with antitumor effect in pancreatic cancer; structure in first source

Also Known As:

3-(2-hydroxyethyl(methyl)amino)-2-quinoxalinecarbonitrile-1,4-dioxide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - TX-2098: 1
- Heterocyclic Oxides
  - Cyclic N-Oxides: 3
    - TX-2098: 1

Experts

1.	Batmunkh, Erdenebulgan: 1 article (08/2012)
2.	Hori, Hitoshi: 1 article (08/2012)
3.	Imura, Satoru: 1 article (08/2012)
4.	Miyake, Kotaro: 1 article (08/2012)
5.	Nagasawa, Hideko: 1 article (08/2012)
6.	Nishioka, Masanori: 1 article (08/2012)
7.	Shimada, Mitsuo: 1 article (08/2012)
8.	Uto, Yoshihiro: 1 article (08/2012)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2012 - "In vitro, TX-2098 inhibited the proliferation of various pancreatic cancer cell lines. " 08/01/2012 - "In s.c model, tumors from nude mice injected with pancreatic cancer cells and treated with TX-2098 showed significant reductions in volume (P<0.01 versus control). " 08/01/2012 - "These results suggest that the effect of TX-2098 in pancreatic cancer might be correlated with the expression of VEGF and HIF-1 targeted molecules." 08/01/2012 - "The antitumor effects of TX-2098 under hypoxia were tested against various human pancreatic cancer cell lines using WST-8 assay. " 08/01/2012 - "The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression."
2.	Neoplasms (Cancer) 08/01/2012 - "In s.c model, tumors from nude mice injected with pancreatic cancer cells and treated with TX-2098 showed significant reductions in volume (P<0.01 versus control). "
3.	Hypoxia (Hypoxemia) 08/01/2012 - "The antitumor effects of TX-2098 under hypoxia were tested against various human pancreatic cancer cell lines using WST-8 assay. " 08/01/2012 - "The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression."

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