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9- trifluoromethyl- 2- ((5- (3- (dimethylamino)propyl)- 2- methylpyridin- 3- yl)amino)- 5,7- dihydro- 6H- pyrimido(5,4- d)(1)benzazepine- 6- thione

inhibits polo-like kinase-1; structure in first source

Also Known As:

MLN0905

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - 9-trifluoromethyl-2-((5-(3-(dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-5,7-dihydro-6H-pyrimido(5,4-d)(1)benzazepine-6-thione: 1
Inorganic Chemicals: 9
- Thiones: 70
  - 9-trifluoromethyl-2-((5-(3-(dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-5,7-dihydro-6H-pyrimido(5,4-d)(1)benzazepine-6-thione: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiones: 70
    - 9-trifluoromethyl-2-((5-(3-(dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-5,7-dihydro-6H-pyrimido(5,4-d)(1)benzazepine-6-thione: 1

Experts

1.	Amidon, Benjamin S: 1 article (09/2012)
2.	D' Amore, Natalie: 1 article (09/2012)
3.	Driscoll, Denise: 1 article (09/2012)
4.	Duffey, Matt O: 1 article (09/2012)
5.	Hyer, Marc L: 1 article (09/2012)
6.	Lasky, Kerri: 1 article (09/2012)
7.	Liao, Debra: 1 article (09/2012)
8.	Liu, Ray: 1 article (09/2012)
9.	Manfredi, Mark G: 1 article (09/2012)
10.	Nestor, Michelle Tighe: 1 article (09/2012)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2012 - "We have discovered an experimental, potent, and selective small-molecule inhibitor of PLK1, MLN0905, which inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. " 09/01/2012 - "These studies indicate that MLN0905 modulates the pharmacodynamic biomarker phosphorylated histone H3 (pHisH3) in tumor tissue. "
2.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/01/2012 - "MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma."
3.	Lymphoma (Lymphomas) 09/01/2012 - "The antitumor activity of MLN0905 was evaluated in three human subcutaneous DLBCL xenograft models, OCI LY-10, OCI LY-19, and PHTX-22L (primary lymphoma). "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Histones (Histone)