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3- cyclopropylmethyl- 7- phenyl- 3H- pyrrolo(3,2- f)quinolin- 9(6H)- one

a tubulin inhibitor; structure in first source

Also Known As:

MG 2477; MG-2477; MG2477

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 3-cyclopropylmethyl-7-phenyl-3H-pyrrolo(3,2-f)quinolin-9(6H)-one: 2
    - Quinolines: 146
      - Quinolones: 2938
        3-cyclopropylmethyl-7-phenyl-3H-pyrrolo(3,2-f)quinolin-9(6H)-one: 2

Experts

1.	Ferlin, Maria Grazia: 2 articles (05/2017 - 01/2012)
2.	Viola, Giampietro: 2 articles (05/2017 - 01/2012)
3.	Ausserlechner, Michael J: 1 article (05/2017)
4.	Hagenbuchner, Judith: 1 article (05/2017)
5.	Kiechl-Kohlendorfer, Ursula: 1 article (05/2017)
6.	Lungkofler, Lorena: 1 article (05/2017)
7.	Obexer, Petra: 1 article (05/2017)
8.	Basso, Giuseppe: 1 article (01/2012)
9.	Bortolozzi, Roberta: 1 article (01/2012)
10.	Brun, Paola: 1 article (01/2012)

Related Diseases

1.	Neuroblastoma 05/09/2017 - "The combined data suggest that MG-2477 induces a sequential process of ROS-accumulation, autophagy and FOXO3-activation that leads to cell death in neuroblastoma cells." 05/09/2017 - "The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma." 05/09/2017 - "Here we studied the tubulin-inhibitor MG-2477 as a possible therapeutic agent for neuroblastoma therapy and uncovered that MG-2477 induces death in neuroblastoma cells independent of PKB-activation status and stage. "
2.	Neoplasms (Cancer) 01/01/2012 - "We previously demonstrated that MG-2477 (3-cyclopropylmethyl-7-phenyl-3H-pyrrolo[3,2-f]quinolin-9(6H)-one) inhibits the growth of several cancer cell lines in vitro. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2012 - "The detailed mechanism of action of MG-2477 was investigated in a non-small cell lung carcinoma cell line (A549). "

Related Drugs and Biologics

1.	Tubulin Modulators

Related Therapies and Procedures

1.	Therapeutics