N- (3- (6- (4- (1,4- dimethyl- 3- oxopiperazin- 2- yl)phenylamino)- 4- methyl- 5- oxo- 4,5- dihydropyrazin- 2- yl)- 2- methylphenyl)- 4,5,6,7- tetrahydrobenzo(b)thiophene- 2- carboxamide

an anti-arthritis agent that inhibits Bruton's tyrosine kinase; structure in first source

Also Known As:

GDC 0834; GDC-0834; GDC0834

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide: 3
  - Thiophenes: 257
    - N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide: 3

Experts

1.	Liu, Lichuan: 2 articles (06/2015 - 07/2011)
2.	Barr, John T: 1 article (06/2015)
3.	Halladay, Jason S: 1 article (06/2015)
4.	Hop, Cornelis E C A: 1 article (06/2015)
5.	Jones, Jeffrey P: 1 article (06/2015)
6.	Khojasteh, S Cyrus: 1 article (06/2015)
7.	Kirkpatrick, Donald S: 1 article (06/2015)
8.	Sodhi, Jasleen K: 1 article (06/2015)
9.	Wong, Susan: 1 article (06/2015)
10.	Robak, Ewa: 1 article (07/2012)

Related Diseases

1.	Rheumatoid Arthritis 06/01/2015 - "GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circulation after oral administration. " 07/01/2012 - "The search terms used were Bruton's tyrosine kinase (Btk) inhibitors, PCI-32765, GDC-0834, LFM-A13, AVL-101, AVL-292, spleen tyrosine kinase (Syk) inhibitors, R343, R406, R112, R788, fostamatinib, BAY-61-3606, C-61, piceatannol, Lyn, imatinib, nilotinib, bafetinib, dasatinib, GDC-0834, PP2, SU6656 in conjunction with lymphoid malignancy, NHL, CLL, autoimmune disease, allergic disease, asthma, and rheumatoid arthritis. "
2.	Neoplasms (Cancer) 07/01/2012 - "The search terms used were Bruton's tyrosine kinase (Btk) inhibitors, PCI-32765, GDC-0834, LFM-A13, AVL-101, AVL-292, spleen tyrosine kinase (Syk) inhibitors, R343, R406, R112, R788, fostamatinib, BAY-61-3606, C-61, piceatannol, Lyn, imatinib, nilotinib, bafetinib, dasatinib, GDC-0834, PP2, SU6656 in conjunction with lymphoid malignancy, NHL, CLL, autoimmune disease, allergic disease, asthma, and rheumatoid arthritis. "
3.	Autoimmune Diseases (Autoimmune Disease) 07/01/2012 - "The search terms used were Bruton's tyrosine kinase (Btk) inhibitors, PCI-32765, GDC-0834, LFM-A13, AVL-101, AVL-292, spleen tyrosine kinase (Syk) inhibitors, R343, R406, R112, R788, fostamatinib, BAY-61-3606, C-61, piceatannol, Lyn, imatinib, nilotinib, bafetinib, dasatinib, GDC-0834, PP2, SU6656 in conjunction with lymphoid malignancy, NHL, CLL, autoimmune disease, allergic disease, asthma, and rheumatoid arthritis. "
4.	Asthma (Bronchial Asthma) 07/01/2012 - "The search terms used were Bruton's tyrosine kinase (Btk) inhibitors, PCI-32765, GDC-0834, LFM-A13, AVL-101, AVL-292, spleen tyrosine kinase (Syk) inhibitors, R343, R406, R112, R788, fostamatinib, BAY-61-3606, C-61, piceatannol, Lyn, imatinib, nilotinib, bafetinib, dasatinib, GDC-0834, PP2, SU6656 in conjunction with lymphoid malignancy, NHL, CLL, autoimmune disease, allergic disease, asthma, and rheumatoid arthritis. "
5.	Experimental Arthritis 07/01/2011 - "Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology. "

Related Drugs and Biologics

1.	Agammaglobulinaemia Tyrosine Kinase
2.	Amides
3.	Syk Kinase
4.	Dasatinib (BMS 354825)
5.	Imatinib Mesylate (Gleevec)
6.	ibrutinib
7.	fostamatinib
8.	bafetinib
9.	nilotinib
10.	2- (7- (3,4- dimethoxyphenyl)imidazo(1,2- c)pyrimidin- 5- ylamino)nicotinamide

Related Therapies and Procedures

1.	Oral Administration