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6-O-angeloylprenolin

from Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase); structure in first source

Also Known As:

6-O-angeloylplenolin; 6-OAP cpd

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - 6-O-angeloylprenolin: 7
- Lactones: 1549
  - 6-O-angeloylprenolin: 7

Experts

1.	Cheng, Yong-Xian: 4 articles (01/2020 - 01/2011)
2.	Liu, Yong-Qiang: 2 articles (01/2020 - 01/2017)
3.	Zhou, Guang-Biao: 2 articles (01/2017 - 01/2011)
4.	Liu, Ying: 2 articles (08/2013 - 01/2011)
5.	Zhang, Bo: 2 articles (08/2013 - 01/2011)
6.	He, Dan-Hua: 1 article (01/2020)
7.	Hu, Ling: 1 article (01/2020)
8.	Li, Si-Yi: 1 article (01/2020)
9.	Liu, Wei: 1 article (01/2020)
10.	Pan, Hua-Feng: 1 article (01/2020)

Related Diseases

1.	Neuroinflammatory Diseases 01/01/2020 - "6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo." 01/01/2020 - "In this study, we investigated the effects of a natural sesquiterpene lactone, 6-O-angeloylplenolin (6-OAP), isolated from the traditional Chinese medicine Centipeda minima (L.) A.Br., on neuroinflammation and the underlying mechanisms. "
2.	Multiple Myeloma 08/01/2013 - "Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells." 01/01/2011 - "Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma." 08/01/2013 - "6-O-angeloylplenolin (6-OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. "
3.	Sinusitis 02/01/1998 - "Centipeda minima, a herb used medicinally to treat sinus infections in Nepal, was found to contain three antibacterial sesquiterpene lactones, identified as 6-O-methylacrylylplenolin, 6-O-isobutyroylplenolin, and 6-O-angeloylplenolin. "
4.	Lung Neoplasms (Lung Cancer) 01/10/2017 - "Targeting of Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation and degradation of Skp2 and mitotic arrest of lung cancer cells. "
5.	Carcinoma (Carcinomatosis) 06/01/2018 - "Sesquiterpene lactone 6-O-angeloylplenolin reverses vincristine resistance by inhibiting YB-1 nuclear translocation in colon carcinoma cells."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Cyclin B1
4.	S-Phase Kinase-Associated Proteins (Skp1 Protein)
5.	Vincristine (Oncovin)
6.	Lipopolysaccharides
7.	anti-IgE antibodies

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)