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chlorambucil N-oxide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        Chlorambucil: 1430
        chlorambucil N-oxide: 1
Heterocyclic Compounds: 198
- Heterocyclic Oxides
  - Cyclic N-Oxides: 3
    - chlorambucil N-oxide: 1

Related Diseases

1.

Hypoxia (Hypoxemia)

03/31/1995 - "Comparison of NMR spectra showed that a recent published synthesis of 4 in fact resulted in the rearrangement product 11, indicating that recent reported investigations of the hypoxia-selective cytotoxicity and metabolism of chlorambucil N-oxide have examined this rearrangement product rather than 4. In a clonogenic assay, 4 was less cytotoxic against AA8 cells than was chlorambucil, but the effect of oxygen on cytotoxicity was no greater than for chlorambucil itself."
03/31/1995 - "The potential hypoxia-selective cytotoxin 4-[4'-[N,N-bis(2"-chloroethyl)amino]phenyl]butanoic acid N-oxide (chlorambucil N-oxide, 4) was synthesized and characterized as its hydrochloride salt. "

Related Drugs and Biologics

1.	Butyric Acid (Butanoic Acid)
2.	Salts
3.	Oxygen (Dioxygen)
4.	Oxides
5.	Cytotoxins (Cytolysins)
6.	Chlorambucil (Leukeran)