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FR 66973
antitumor antibiotic from Streptomyces sandaensis; more potent against B16 melanoma & P388 leukemia than mitomycin C; structure given in first source
Also Known As:
FR-66973; FR66973; 3,9-Epoxy-3H-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 1-acetyl-7,9-bis(acetyloxy)-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Quinones: 434
Indolequinones: 12
Mitomycins: 11
FR 66973: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azirines
Mitomycins: 11
FR 66973: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indolequinones: 12
Mitomycins: 11
FR 66973: 1
Related Diseases
1.
Neoplasms (Cancer)
12/01/1987 - "
The overall in vitro response rate (defined as less than 50% survival of tumor colony forming units) for FR66973 against fresh tumor cells obtained from patients with non-small cell lung carcinoma (NSCLC) was 32%, 50% and 89% at 0.1, 1 and 10 micrograms/ml, respectively, which was superior to that of mitomycin C at the corresponding concentration.
"
12/01/1987 - "
We have utilized a human tumor clonogenic assay (HTCA), as a disease-oriented drug screening model of new antitumor drugs, to test the antitumor activity of FR66973 and compared the activity with that of its analogous compound, mitomycin C.
"
2.
Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/01/1987 - "
A new antitumor antibiotic FR66973: clonogenic in vitro assessment of activity against human non-small cell lung carcinoma.
"
12/01/1987 - "
The overall in vitro response rate (defined as less than 50% survival of tumor colony forming units) for FR66973 against fresh tumor cells obtained from patients with non-small cell lung carcinoma (NSCLC) was 32%, 50% and 89% at 0.1, 1 and 10 micrograms/ml, respectively, which was superior to that of mitomycin C at the corresponding concentration.
"
Related Drugs and Biologics
1.
Mitomycin (Mitomycin-C)
2.
Antineoplastic Agents (Antineoplastics)
3.
Anti-Bacterial Agents (Antibiotics)
4.
2'- (2- hydroxyphenyl)- 2'- thiazoline- 4'- carboxylic acid