trichothecolone

RN given refers to (4beta)-isomer; RN for cpd without isomeric designation not in Chemline 4/86

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 07/01/1990 - "Both in vitro and in vivo data suggest that trichothecolone may be an interesting antitumor agent, particularly considering the clear difference in sensitivity of normal and tumor cells to this drug." 06/12/2003 - "Bioassay-guided separation of extracts from the culture broth and mycelium of the fungus Trichothecium roseum, aiming at the discovery for cancer preventive agents, resulted in the isolation of three new trichothecene sesquiterpenes, trichothecinols A-C (1-3) together with three known analogues, trichothecin (4), trichodermol (5) and trichothecolone (6). "
2.	Leukemia P388 07/01/1990 - "In vivo, trichothecolone significantly increased the survival of mice bearing P388 leukemia: a 150 mg/kg/dose, 5 times a day, for 5 days led to a T/C of 145%. "

1.	Trichodermin
2.	Sesquiterpenes
3.	Antineoplastic Agents (Antineoplastics)
4.	trichothecin
5.	trichothecene