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PU-91

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- PU-91: 2

Experts

1.	Chwa, Marilyn: 1 article (01/2019)
2.	Federoff, Howard: 1 article (01/2019)
3.	Kenney, M Cristina: 1 article (01/2019)
4.	Kuppermann, Baruch D: 1 article (01/2019)
5.	Nashine, Sonali: 1 article (01/2019)
6.	Nesburn, Anthony: 1 article (01/2019)
7.	Subramaniam, Sudhakar R: 1 article (01/2019)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 01/01/2019 - "PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics." 06/22/2023 - "Potential Therapeutic Functions of PU-91 and Quercetin in Personalized Cybrids Derived from Patients with Age-Related Macular Degeneration, Keratoconus, and Glaucoma." 06/22/2023 - "The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration (AMD), glaucoma (Glc), keratoconus (KC), and normal (NL) individuals. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2019 - "Since mitochondrial dysfunction is implicated in the pathogenesis of AMD, this study is based on the premise that repurposing of mitochondria-stabilizing FDA-approved drugs such as PU-91, might rescue AMD RPE cells from AMD mitochondria-induced damage. "
3.	Keratoconus 06/22/2023 - "Potential Therapeutic Functions of PU-91 and Quercetin in Personalized Cybrids Derived from Patients with Age-Related Macular Degeneration, Keratoconus, and Glaucoma." 06/22/2023 - "The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration (AMD), glaucoma (Glc), keratoconus (KC), and normal (NL) individuals. "
4.	Glaucoma 06/22/2023 - "Potential Therapeutic Functions of PU-91 and Quercetin in Personalized Cybrids Derived from Patients with Age-Related Macular Degeneration, Keratoconus, and Glaucoma." 06/22/2023 - "The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration (AMD), glaucoma (Glc), keratoconus (KC), and normal (NL) individuals. "

Related Drugs and Biologics

1.	Quercetin
2.	Mitochondrial DNA (mtDNA)

Related Therapies and Procedures

1.	Therapeutics