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3(S)-thiomethyl pyrrolidine

ERK inhibitor used in oncology

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 3(S)-thiomethyl pyrrolidine: 1

Experts

1.	Alhassan, Abdul Basit: 1 article (07/2018)
2.	Bishop, Robert: 1 article (07/2018)
3.	Black, Stuart: 1 article (07/2018)
4.	Boga, Sobhana Babu: 1 article (07/2018)
5.	Buevich, Alexei: 1 article (07/2018)
6.	Carr, Donna: 1 article (07/2018)
7.	Cooper, Alan B: 1 article (07/2018)
8.	Cox, Kathleen: 1 article (07/2018)
9.	Dayananth, Priya: 1 article (07/2018)
10.	Deng, Yongqi: 1 article (07/2018)

Related Diseases

1.	Neoplasms (Cancer) 07/12/2018 - "The challenge of PK was overcome by the discovery of a novel 3(S)-thiomethyl pyrrolidine analog 7. Lead optimization through focused structure-activity relationship led to the discovery of a clinical candidate MK-8353 suitable for twice daily oral dosing as a potential new cancer therapeutic."

Related Drugs and Biologics

1.	MK-8353