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1- benzyl- 2- (5- methyl- 2- furyl)benzimidazole

a thromboxane A2 receptor antagonist with antiplatelet activity; structure in first source

Also Known As:

nstpbp5185

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 1-benzyl-2-(5-methyl-2-furyl)benzimidazole: 2

Experts

1.	Huang, Shiu-Wen: 2 articles (01/2018 - 01/2016)
2.	Huang, Tur-Fu: 2 articles (01/2018 - 01/2016)
3.	Kuo, Sheng-Chu: 2 articles (01/2018 - 01/2016)
4.	Lien, Jin-Cherng: 2 articles (01/2018 - 01/2016)
5.	Hsu, Ming-Tsung: 1 article (01/2016)
6.	Kuo, Heng-Lan: 1 article (01/2016)
7.	Lin, Shu-Wha: 1 article (01/2016)
8.	Peng, Hui-Chin: 1 article (01/2016)
9.	Tseng, Yufeng Jane: 1 article (01/2016)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/2016 - "This study suggests nstpbp5185, an orally selective anti-thrombotic agent, acting through blockade of TXA2 receptor, may be efficacious for prevention or treatment of pathologic thrombosis." 01/01/2016 - "A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models." 01/01/2016 - "In murine thrombosis models, nstpbp5185 significantly prolonged the latent period in triggering platelet plug formation in mesenteric and FeCl3-induced thrombi formation, and increased the survival rate in pulmonary embolism model with less bleeding than aspirin. "
2.	Neointima 01/01/2018 - "However, nstpbp5185 significantly reduced neointima formation and aortic atherosclerotic lesion area. "
3.	Atherosclerosis 01/01/2018 - "Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice." 01/01/2018 - "Nstpbp5185 and aspirin were orally administered daily for 12 weeks in high-cholesterol-fed ApoE-deficient mice to examine their anti-atherosclerosis effects. "
4.	Pulmonary Embolism 01/01/2016 - "In murine thrombosis models, nstpbp5185 significantly prolonged the latent period in triggering platelet plug formation in mesenteric and FeCl3-induced thrombi formation, and increased the survival rate in pulmonary embolism model with less bleeding than aspirin. "
5.	Hemorrhage 01/01/2016 - "In murine thrombosis models, nstpbp5185 significantly prolonged the latent period in triggering platelet plug formation in mesenteric and FeCl3-induced thrombi formation, and increased the survival rate in pulmonary embolism model with less bleeding than aspirin. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Prostaglandin H2 Thromboxane A2 Receptors
3.	Thromboxane Receptors (Thromboxane Receptor)
4.	Cholesterol
5.	Apolipoproteins E (ApoE)