HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

UAMC-2526

an ATG4B inhibitor with antineoplastic activity; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        Tropolone: 44
        UAMC-2526: 2

Experts

1.	De Meyer, Guido R Y: 2 articles (01/2021 - 01/2017)
2.	Martinet, Wim: 2 articles (01/2021 - 01/2017)
3.	Stroobants, Sigrid: 2 articles (01/2021 - 01/2017)
4.	Van Der Veken, Pieter: 2 articles (01/2021 - 01/2017)
5.	Vangestel, Christel: 2 articles (01/2021 - 01/2017)
6.	Berg, Maya: 1 article (01/2021)
7.	De Bruycker, Sven: 1 article (01/2021)
8.	Pintelon, Isabel: 1 article (01/2021)
9.	Takhsha, Farnaz Sedigheh: 1 article (01/2021)
10.	Tanc, Muhammet: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "However, in contrast to in vitro experiments with Panc02 cells in culture, we were unable to detect autophagy inhibition by UAMC-2526 in Panc02 tumor tissue, neither via western blot analysis of autophagy markers LC3 and p62, nor by transmission electron microscopy. " 01/01/2021 - "Altogether, we conclude that although the combination treatment of UAMC-2526 with gemcitabine did not inhibit autophagy in the Panc02 mouse model, it has a beneficial effect on tumor growth inhibition." 01/01/2021 - "Our data showed that UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments. " 01/01/2017 - "Moreover, addition of UAMC-2526 to the chemotherapy drug oxaliplatin significantly improved inhibition of tumor growth. "
2.	Adenocarcinoma 01/01/2021 - "In this study, we aimed to investigate the potential beneficial effects of UAMC-2526 in a syngeneic Panc02 mouse model of pancreatic ductal adenocarcinoma (PDAC). " 01/01/2021 - "ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma."
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2021 - "Recently, we showed the add-on effect of autophagy inhibitor UAMC-2526 to prevent HT-29 colorectal tumor growth in CD1-/- Foxn1nu mice treated with oxaliplatin. "

Related Drugs and Biologics

1.	Oxaliplatin (Eloxatin)
2.	Gemcitabine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)