Tropolone

10/07/2023 - "These data suggest that the two Cu(II) tropolone derivatives are also interesting candidates to be further tested in in vivo models as an anti-invasive tumor strategy."
06/02/2021 - "Background: β-thujaplicin, a natural tropolone derivative, has anticancer effects on various cancer cells via apoptosis. "
11/01/2003 - "Twenty-seven tropolone derivatives were investigated for their tumor-specific cytotoxicity, using 3 normal human cells and 3 human oral tumor cell lines. "
01/01/2022 - "ß-Thujaplicin, a natural tropolone derivative, acts as an anti-cancer agent and has recently been shown to radiosensitize non-HNSCC cancer cells. "
01/01/2017 - "Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. "

10/01/1986 - "The concentrations of these drugs needed for this decrease were nearly comparable to those needed to suppress isoprenaline-tropolone-induced ventricular fibrillation (Sono et al. 1985a). "
12/01/1985 - "When the hearts were perfused with isoprenaline (1 mumol/liter) in the presence of tropolone (100 mumol/liter) at 40-41 degrees C, the duration of ventricular fibrillations was significantly prolonged, but the incidence of ventricular fibrillations was similar to that produced with isoprenaline (1 mumol/liter) alone. "
10/01/1985 - "There was a significant correlation for dependence of duration of ventricular fibrillation on the isoprenaline content of rat hearts perfused with various extraneuronal uptake inhibitors in the presence of tropolone (correlation coefficient [r] = 0.62, P less than 0.001). "
10/01/1985 - "The accumulation of isoprenaline was significantly increased and the duration of ventricular fibrillation was significantly prolonged by the presence of tropolone (100 mumol/l). "
12/01/1985 - "These results indicate that ventricular fibrillation induced by combined treatment with a high concentration of isoprenaline and tropolone at a high perfusion temperature in isolated rat hearts is a more useful experimental model of arrhythmia than conventional models."

11/23/2015 - "The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. "
08/01/2022 - "This work evaluated key chemical and biological properties of five candidate phytochelators for iron overload diseases: maltol, mimosine, morin, tropolone, and esculetin. "

04/01/2018 - "Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. "

08/01/2022 - "Tropolone derivative hinokitiol ameliorates cerulein-induced acute pancreatitis in mice."