AKI603

11/08/2016 - "Taken together, our data demonstrate that the small molecule AurA inhibitor AKI603 may be used to overcome drug resistance induced by BCR-ABL-T315I mutation in CML."
11/08/2016 - "Surprisingly, inhibition of AurA by AKI603 induced leukemia cell senescence in both BCR-ABL wild type and T315I mutation cells. "
11/08/2016 - "In this study, we investigated the effect of AKI603, a novel small molecule inhibitor of Aurora kinase A (AurA) to overcome resistance mediated by BCR-ABL-T315I mutation. "
06/05/2016 - "Determination of a novel Aurora-A (AurA) kinase AKI603 by UPLC-MS/MS and its application to a bioavailability study in rat."
08/01/2014 - "AKI603 significantly inhibited Aurora-A (AurA) kinase and induced cell-cycle arrest. "

01/01/2015 - "AKI603 inhibited cell viability, and induced cell cycle arrest with polyploidy accumulation in KBM5 and KBM5-T315I cells. "
11/08/2016 - "AKI603 inhibited cell proliferation and colony formation capacities in imatinib-resistant CML cells by inducing cell cycle arrest with polyploidy accumulation. "

11/08/2016 - "Moreover, the anti-tumor effect of AKI603 was proved in the BALB/c nude mice KBM5-T315I xenograft model. "
08/01/2014 - "In addition, the intragastric administration of AKI603 reduced xenograft tumor growth. "

08/01/2014 - "Here, we evaluated the small molecule Aurora kinase inhibitor AKI603 as a novel agent against TICs in breast cancer. "
08/01/2014 - "The inhibition of AurA kinase by AKI603 abolished the epirubicin-induced enrichment of TICs. "

11/08/2016 - "Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation."