Michiel van der Flier Selected Research

Biomarkers (Surrogate Marker)

2/2024	Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases.
7/2023	A Novel Combination of Host Protein Biomarkers to Distinguish Bacterial From Viral Infections in Febrile Children in Emergency Care.
1/2021	Development and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE, a prospective observational study.
1/2021	A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies.

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Michiel van der Flier Research Topics

Disease

13	Infections 03/2024 - 01/2016
12	Bacterial Infections (Bacterial Infection) 01/2023 - 01/2018
8	Sepsis (Septicemia) 12/2022 - 01/2005
6	Virus Diseases (Viral Diseases) 08/2023 - 07/2019
4	Fever (Fevers) 01/2023 - 01/2020
4	Agammaglobulinemia (Hypogammaglobulinemia) 01/2022 - 01/2017
4	Respiratory Tract Infections (Respiratory Tract Infection) 01/2022 - 01/2018
3	Meningitis 01/2022 - 11/2009
3	Reinfection 01/2021 - 01/2018
3	Inflammation (Inflammations) 01/2020 - 01/2016
2	Meningococcal Infections 12/2022 - 04/2014
2	Neonatal Sepsis 01/2022 - 01/2013
2	Critical Illness (Critically Ill) 01/2022 - 10/2021
2	Hereditary Complement Deficiency Diseases 01/2020 - 01/2020
2	Neoplasms (Cancer) 01/2014 - 01/2013
1	COVID-19 related pediatric multisystem inflammatory disease 02/2024
1	Urinary Tract Infections (Urinary Tract Infection) 01/2022
1	Atypical Hemolytic Uremic Syndrome 01/2022
1	Shock 01/2022
1	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2021
1	Primary Immunodeficiency Diseases 01/2021
1	Exanthema (Rash) 01/2021
1	Disease Susceptibility (Diathesis) 01/2020
1	Angioedema 01/2020
1	Communicable Diseases (Infectious Diseases) 07/2019
1	IgA Deficiency 01/2018
1	Discitis 01/2018
1	Pneumococcal Infections 01/2018
1	Constrictive Pericarditis 05/2016
1	Hypersensitivity (Allergy) 01/2014
1	Microcephaly 01/2014
1	Nijmegen Breakage Syndrome 01/2014
1	Human Influenza (Influenza) 01/2013
1	Septic Shock (Toxic Shock Syndrome) 01/2013
1	Febrile Neutropenia 05/2009
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/2009
1	Rhinosinusitis 05/2009
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 05/2009
1	Infarction (Infarctions) 05/2009
1	Cryptococcal Meningitis 10/2004
1	Brain Edema (Cerebral Edema) 07/2004
1	Tuberculosis (Tuberculoses) 07/2004
1	Meningeal Tuberculosis (Tuberculous Meningitis) 07/2004

Drug/Important Bio-Agent (IBA)

10	Anti-Bacterial Agents (Antibiotics)IBA 02/2023 - 01/2016
7	Proteins (Proteins, Gene)FDA Link 08/2023 - 11/2009
6	Immunoglobulin G (IgG)IBA 01/2022 - 05/2016
6	Complement System Proteins (Complement)IBA 01/2021 - 04/2014
4	C-Reactive ProteinIBA 03/2024 - 01/2021
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2021
4	Immunoglobulin M (IgM)IBA 01/2022 - 01/2017
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2013 - 07/2004
3	Immunoglobulin A (IgA)IBA 01/2022 - 01/2018
3	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 01/2018
3	Complement Factor H (Factor H)IBA 01/2018 - 01/2016
2	Blood Proteins (Serum Proteins)IBA 02/2024 - 07/2023
2	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 10/2021 - 01/2016
2	CytokinesIBA 12/2016 - 01/2016
2	CEACAM1 ProteinIBA 01/2013 - 11/2009
1	ProteomeIBA 08/2023
1	GlycopeptidesIBA 08/2023
1	Interleukin-6 (Interleukin 6)IBA 07/2023
1	Hemostatics (Antihemorrhagics)IBA 12/2022
1	Fibronectins (Fibronectin)IBA 12/2022
1	ThrombomodulinIBA 12/2022
1	Cefotaxime (Kendrick)FDA LinkGeneric 01/2022
1	eculizumab FDA Link 01/2022
1	Complement C8 (C8 Complement)IBA 11/2021
1	VaccinesIBA 11/2021
1	Metalloproteases (Metalloproteinases)IBA 11/2021
1	DisintegrinsIBA 11/2021
1	ThrombospondinsIBA 11/2021
1	Complement Factor D (Factor D)IBA 01/2021
1	ResistinIBA 01/2021
1	SPADIBA 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	AntibodiesIBA 01/2020
1	Complement Inactivating AgentsIBA 01/2020
1	ClusterinIBA 07/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2018
1	Immunoglobulin IsotypesIBA 01/2018
1	Choline (Choline Chloride)IBA 01/2018
1	human CFH proteinIBA 01/2016
1	Ligases (Synthetase)IBA 01/2014
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2013
1	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 09/2013
1	Voriconazole (Vfend)FDA LinkGeneric 05/2009
1	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2004

Therapy/Procedure

7	Therapeutics 01/2022 - 05/2009
2	Antibiotic Prophylaxis 01/2021 - 01/2018
1	Critical Care (Surgical Intensive Care) 01/2023
1	Skin Transplantation (Skin Grafting) 01/2022
1	Surgical Amputation (Amputations) 01/2022
1	Vascular Access Devices (Arterial Line) 10/2021
1	Pericardiectomy 05/2016
1	Drug Therapy (Chemotherapy) 01/2013
1	Debridement 05/2009
1	Induction Chemotherapy 05/2009