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David I Yule Selected Research

Neoplasms (Cancer)

1/2022Metabolic adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter.
1/2020Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.
1/2020Critical Role of Mortalin/GRP75 in Endothelial Cell Dysfunction Associated with Acute Lung Injury.
8/2016The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.
9/2015The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.
3/2015The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.

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David I Yule Research Topics

Disease

6Neoplasms (Cancer)
01/2022 - 03/2015
4Inflammation (Inflammations)
10/2023 - 01/2019
4Pancreatitis
01/2021 - 02/2011
2Bites and Stings (Sting)
03/2024 - 01/2022
2Acute Lung Injury
01/2020 - 01/2019
2Cardiomegaly (Heart Hypertrophy)
11/2018 - 03/2013
1Inborn Genetic Diseases (Disease, Hereditary)
05/2024
1Cystic Fibrosis (Mucoviscidosis)
05/2024
1Bacterial Infections (Bacterial Infection)
03/2024
1Xerostomia
01/2024
1Autoimmune Diseases (Autoimmune Disease)
01/2024
1Pain (Aches)
10/2023
1Heart Failure
11/2022
1Aortic Aneurysm (Aneurysm, Aortic)
01/2022
1Abdominal Aortic Aneurysm
01/2022
1Myocardial Infarction
01/2021
1Dental Fluorosis
01/2020
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2020
1Hemorrhage
01/2019
1Necrosis
10/2018
1Starvation
06/2017
1Hyperthermia
11/2016
1Hypohidrosis
11/2016
1Disease Progression
09/2015
1Hypoxia (Hypoxemia)
01/2012
1Pancreatic Diseases (Pancreatic Disease)
02/2011
1Alzheimer Disease (Alzheimer's Disease)
03/2010
1Amyloid Plaque
03/2010
1Neuroinflammatory Diseases
03/2010
1Pathologic Processes
10/2009
1Infections
09/2008
1Prostatic Neoplasms (Prostate Cancer)
02/2006
1AIDS-Related Complex (ARC)
05/2005

Drug/Important Bio-Agent (IBA)

3Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA
11/2022 - 03/2015
3Proteins (Proteins, Gene)FDA Link
01/2020 - 09/2008
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2021 - 11/2018
2Cholecystokinin (Pancreozymin)IBA
01/2021 - 05/2005
2ThrombinFDA Link
01/2020 - 02/2011
2phosphatidylinositol 4-phosphateIBA
11/2018 - 03/2013
2Phosphotransferases (Kinase)IBA
11/2018 - 02/2006
2CytokinesIBA
09/2015 - 10/2009
2Phospholipases (Phospholipase)IBA
03/2013 - 05/2005
2Carbachol (Carbastat)FDA Link
01/2012 - 05/2005
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2010 - 10/2009
1Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
05/2024
1InterferonsIBA
03/2024
1RibonucleotidesIBA
03/2024
1vadimezanIBA
03/2024
1Toll-Like Receptor 8IBA
01/2024
1AutoantibodiesIBA
01/2024
1Transient Receptor Potential ChannelsIBA
10/2023
1LipidsIBA
10/2023
1Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
01/2022
1Odorant Receptors (Odorant Receptor)IBA
01/2022
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2022
1Protein Isoforms (Isoforms)IBA
01/2022
1Tricarboxylic AcidsIBA
01/2022
1Oxidoreductases (Dehydrogenase)IBA
01/2022
1cyclic guanosine monophosphate-adenosine monophosphateIBA
01/2022
1Proteinase-Activated ReceptorsIBA
01/2021
1CeruletideIBA
01/2021
1Glucose (Dextrose)FDA LinkGeneric
01/2020
1FluoridesIBA
01/2020
1glucose-regulated proteinsIBA
01/2020
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
01/2020
1mortalinIBA
01/2020
1Donepezil (Aricept)FDA LinkGeneric
01/2019
1Endoplasmic Reticulum Chaperone BiPIBA
01/2019
1Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2019
1HoloenzymesIBA
01/2019
1Nuclear Proteins (Protein, Nuclear)IBA
11/2018
1Adenosine Triphosphate (ATP)IBA
10/2018
1Enzyme Precursors (Zymogens)IBA
10/2018
1Sirolimus (Rapamycin)FDA Link
06/2017
1Inositol 1,4,5-TrisphosphateIBA
06/2017
1Calcium Release Activated Calcium ChannelsIBA
11/2016
1venetoclaxIBA
08/2016
1Apoptosis Regulatory ProteinsIBA
09/2015
1CalciumIBA
03/2015
1TrypsinIBA
02/2011
12-acetylpyridine semicarbazoneIBA
02/2011
1tetrandrineIBA
05/2005
1Arachidonic Acid (Vitamin F)IBA
05/2005

Therapy/Procedure

3Therapeutics
10/2023 - 01/2020
1Aftercare (After-Treatment)
01/2020
1Carbohydrate Loading Diet
10/2018