Stefan Wirtz Selected Research

Interleukin-6 (Interleukin 6)

12/2022	PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells.
3/2014	A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.
5/2012	A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.
6/2011	IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo.
7/2009	STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing.
7/2008	The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
12/2007	Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
3/2007	Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.
10/2004	TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
1/2003	A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis.

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Stefan Wirtz Research Topics

Disease

39	Inflammation (Inflammations) 11/2023 - 05/2003
32	Colitis 11/2023 - 01/2002
15	Infections 01/2023 - 04/2005
14	Neoplasms (Cancer) 02/2023 - 10/2004
12	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2023 - 08/2005
7	Ulcerative Colitis 10/2021 - 03/2005
7	Crohn Disease (Crohn's Disease) 11/2019 - 01/2002
6	Carcinogenesis 02/2023 - 04/2010
6	Colorectal Neoplasms (Colorectal Cancer) 12/2022 - 10/2004
6	Arthritis (Polyarthritis) 01/2020 - 09/2006
5	Fibrosis (Cirrhosis) 01/2020 - 08/2013
4	Colonic Neoplasms (Colon Cancer) 02/2023 - 10/2004
4	Dysbiosis 01/2021 - 01/2020
4	Colitis-Associated Neoplasms 07/2015 - 04/2010
3	Necrosis 09/2022 - 01/2017
3	Hepatitis 11/2016 - 01/2007
3	Autoimmune Diseases (Autoimmune Disease) 03/2014 - 04/2003
2	Tuberculosis (Tuberculoses) 01/2023 - 01/2013
2	Bacterial Infections (Bacterial Infection) 11/2022 - 01/2016
2	Hemorrhage 01/2022 - 10/2020
2	Enteritis 01/2022 - 01/2018
2	Critical Illness (Critically Ill) 10/2020 - 05/2003
2	Neurogenic Inflammation 01/2018 - 01/2016
2	Experimental Arthritis 09/2013 - 03/2007
2	Rheumatoid Arthritis 05/2013 - 03/2007
2	Ischemia 01/2004 - 12/2003
1	Alzheimer Disease (Alzheimer's Disease) 04/2024
1	Q Fever (Fever, Q) 01/2023
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2023
1	Hyperplasia 12/2022

Drug/Important Bio-Agent (IBA)

31	CytokinesIBA 01/2023 - 01/2002
10	Interleukin-6 (Interleukin 6)IBA 12/2022 - 01/2003
10	Proteins (Proteins, Gene)FDA Link 09/2022 - 01/2007
9	InterleukinsIBA 10/2023 - 07/2009
8	Interleukin-13IBA 01/2023 - 08/2013
8	Transcription Factors (Transcription Factor)IBA 01/2020 - 11/2007
6	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2020 - 01/2007
6	Dextrans (Dextran)FDA Link 01/2020 - 01/2007
6	OxazoloneIBA 07/2017 - 12/2002
6	Interleukin-27 (Interleukin 27)IBA 11/2011 - 04/2005
5	Interleukin-9 (Interleukin 9)IBA 12/2022 - 07/2014
4	Dextran SulfateIBA 10/2023 - 10/2015
4	Interleukin-17 (Interleukin 17)IBA 01/2023 - 03/2007
4	LigandsIBA 01/2023 - 01/2017
4	EnzymesIBA 01/2023 - 02/2016
4	Caspase 8 (Caspase-8)IBA 01/2022 - 01/2018
4	Sulfonic AcidsIBA 07/2017 - 12/2002
4	Interleukin-12 (IL 12)IBA 01/2017 - 08/2005
4	Interleukin-23 (Interleukin 23)IBA 01/2017 - 09/2003
3	16S Ribosomal RNAIBA 02/2023 - 08/2020
3	Interleukin-10 (Interleukin 10)IBA 01/2023 - 03/2014
3	Interleukin-4 (Interleukin 4)IBA 01/2023 - 01/2007
3	AntigensIBA 01/2023 - 01/2007
3	AlarminsIBA 11/2022 - 01/2017
3	Interleukin-22 (IL-22)IBA 11/2022 - 06/2011
3	AntibodiesIBA 11/2019 - 01/2017
3	Messenger RNA (mRNA)IBA 10/2019 - 01/2002
3	Indicators and Reagents (Reagents)IBA 07/2017 - 01/2007
3	Interleukin-33IBA 01/2017 - 08/2013
3	Interferon-gamma (Interferon, gamma)IBA 10/2015 - 08/2005
3	AzoxymethaneIBA 05/2012 - 04/2010
2	Phosphotransferases (Kinase)IBA 01/2021 - 11/2016
2	Citric Acid (Citrate)FDA LinkGeneric 10/2020 - 01/2019
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2020 - 04/2003
2	Interleukin-5 (Interleukin 5)IBA 01/2020 - 01/2018
2	Interferon Regulatory FactorsIBA 01/2020 - 06/2011
2	Peptides (Polypeptides)IBA 01/2020 - 01/2017
2	Collagen Type VIIBA 01/2020 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 03/2013
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 12/2010
2	Antimicrobial PeptidesIBA 01/2018 - 01/2015
2	HaptensIBA 07/2017 - 01/2007
2	Phenobarbital (Luminal)FDA Link 07/2017 - 01/2007
2	STAT1 Transcription FactorIBA 01/2017 - 11/2016
2	InterferonsIBA 01/2017 - 10/2015
2	Concanavalin AIBA 01/2016 - 12/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2015 - 12/2010
1	PresenilinsIBA 04/2024
1	Interleukin-3 Receptors (Interleukin 3 Receptor)IBA 11/2023
1	Interleukin-3 (Interleukin 3)IBA 11/2023
1	interleukin 20 (IL-20)IBA 10/2023
1	ElementsIBA 02/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2023
1	Recombinant ProteinsIBA 01/2023
1	aconitate decarboxylaseIBA 01/2023
1	Immunoglobulin G (IgG)IBA 01/2023
1	Immunoglobulin A (IgA)IBA 01/2023
1	itaconic acidIBA 01/2023
1	Vancomycin FDA LinkGeneric 01/2023
1	Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA 01/2022
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2021
1	Tec protein-tyrosine kinaseIBA 10/2021
1	ProstaglandinsIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2021
1	Heme (Haem)IBA 01/2021

Therapy/Procedure

10	Therapeutics 02/2023 - 01/2003
2	Transplantation 01/2020 - 07/2008
2	Injections 01/2019 - 01/2017
2	Cell Transplantation 01/2018 - 01/2011
2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2004 - 12/2003