Martin J Whitaker Selected Research

Hydrocortisone (Cortisol)

9/2023	Developing oral chronotherapy for cortisol replacement in congenital adrenal hyperplasia.
3/2023	Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients.
1/2023	Chronotherapy based on modified-release hydrocortisone to restore the physiological cortisol diurnal rhythm.
1/2022	Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis.
1/2022	Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach.
10/2021	Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency.
1/2021	A Prospective Study of Children Aged 0-8 Years with CAH and Adrenal Insufficiency Treated with Hydrocortisone Granules.
12/2020	Response to 'Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia'.
1/2019	Salivary Cortisone to Estimate Cortisol Exposure and Sampling Frequency Required Based on Serum Cortisol Measurements.
1/2019	Accuracy of hydrocortisone dose administration via nasogastric tube.

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Martin J Whitaker Research Topics

Disease

13	Adrenal Insufficiency (Adrenal Gland Hypofunction) 09/2023 - 04/2015
11	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 09/2023 - 03/2015
2	Rare Diseases (Rare Disease) 10/2021 - 12/2018
1	Hypopituitarism (Sheehan's Syndrome) 01/2021
1	Flushing 01/2019
1	Adrenal incidentaloma 01/2019
1	Body Weight (Weight, Body) 01/2018
1	Bone Fractures (Bone Fracture) 01/2016
1	Musculoskeletal Diseases (Musculoskeletal Disease) 07/2004

Drug/Important Bio-Agent (IBA)

17	Hydrocortisone (Cortisol)FDA LinkGeneric 09/2023 - 03/2015
2	SuspensionsIBA 12/2020 - 01/2019
2	GlucocorticoidsIBA 01/2017 - 01/2016
1	Cortisone FDA Link 02/2023
1	Calcium Gluconate (CBG)IBA 01/2022
1	cortisol binding globulinIBA 01/2022
1	Hormones (Hormone)IBA 10/2021
1	TabletsIBA 01/2019
1	Capsules (Microcapsules)IBA 08/2017
1	SteroidsIBA 08/2017
1	AndrogensIBA 01/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2004

Therapy/Procedure

4	Therapeutics 03/2023 - 08/2017
1	Chronotherapy 09/2023