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Le Wang Selected Research

Carcinogenesis

1/2024Usenamine A triggers NLRP3/caspase-1/GSDMD-mediated pyroptosis in lung adenocarcinoma by targeting the DDX3X/SQSTM1 axis.
9/2023Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba.
1/2023FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
1/2022Oridonin Induces Oxidative Stress-mediated Cancer Cells Apoptosis via Targeting Thioredoxin Reductase.
1/2022Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo.
12/2021Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells.
10/2021Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.
4/2014Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.

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Le Wang Research Topics

Disease

95Neoplasms (Cancer)
02/2024 - 04/2003
28Inflammation (Inflammations)
01/2024 - 08/2014
28Infections
12/2023 - 12/2012
20Neoplasm Metastasis (Metastasis)
05/2024 - 06/2011
19Hypoxia (Hypoxemia)
01/2024 - 02/2011
17Fibrosis (Cirrhosis)
02/2024 - 08/2015
16Breast Neoplasms (Breast Cancer)
04/2024 - 04/2011
15Hepatocellular Carcinoma (Hepatoma)
10/2023 - 01/2015
14Thrombosis (Thrombus)
05/2024 - 01/2011
14Stroke (Strokes)
11/2023 - 01/2014
14Hemorrhage
11/2023 - 08/2015
14Glioma (Gliomas)
10/2021 - 01/2012
13Liver Cirrhosis (Hepatic Cirrhosis)
05/2024 - 01/2017
13Lung Neoplasms (Lung Cancer)
01/2024 - 01/2015
13Myocardial Infarction
11/2023 - 01/2014
11Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2024 - 01/2016
10Spinal Cord Injuries (Spinal Cord Injury)
11/2023 - 08/2014
9Acute Coronary Syndrome
10/2023 - 01/2014
9Ischemia
03/2023 - 01/2006
9Heart Failure
01/2022 - 09/2008
8Type 2 Diabetes Mellitus (MODY)
03/2024 - 08/2019
8Hypertension (High Blood Pressure)
02/2024 - 07/2014
8Diabetes Mellitus
02/2024 - 08/2015
8Carcinogenesis
01/2024 - 04/2014
8Wounds and Injuries (Trauma)
01/2024 - 01/2017
8Necrosis
04/2023 - 01/2018
7Epilepsy (Aura)
04/2024 - 01/2019
7Uterine Cervical Neoplasms (Cancer of the Cervix)
11/2022 - 09/2014
7Glioblastoma (Glioblastoma Multiforme)
01/2022 - 04/2015
7Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 01/2014
7Parkinson Disease (Parkinson's Disease)
01/2021 - 11/2014
6Body Weight (Weight, Body)
04/2024 - 09/2013
6Coronary Artery Disease (Coronary Atherosclerosis)
03/2024 - 09/2014
6Adenocarcinoma of Lung
01/2024 - 10/2022
6Pancreatitis
01/2023 - 01/2018
6Ischemic Stroke
01/2023 - 01/2020
6Coronary Disease (Coronary Heart Disease)
01/2022 - 01/2019
6Schizophrenia (Dementia Praecox)
01/2022 - 01/2015
5Pain (Aches)
01/2024 - 03/2018
5Alzheimer Disease (Alzheimer's Disease)
12/2023 - 11/2011
5Reperfusion Injury
10/2023 - 01/2006
5Brain Ischemia (Cerebral Ischemia)
01/2023 - 09/2014
5Osteoporosis
01/2022 - 07/2015
4Obesity
03/2024 - 01/2016
4Portal Hypertension
10/2023 - 02/2020
4Pulmonary Hypertension
04/2023 - 03/2011
4Bipolar Disorder (Manic Depressive Psychosis)
01/2022 - 02/2003

Drug/Important Bio-Agent (IBA)

41Proteins (Proteins, Gene)FDA Link
11/2023 - 01/2011
40Biomarkers (Surrogate Marker)IBA
02/2024 - 01/2012
17MicroRNAs (MicroRNA)IBA
02/2024 - 03/2015
17Messenger RNA (mRNA)IBA
01/2022 - 08/2013
14Long Noncoding RNAIBA
04/2024 - 08/2013
14RNA (Ribonucleic Acid)IBA
12/2023 - 09/2014
11Glucose (Dextrose)FDA LinkGeneric
01/2023 - 01/2013
10Anti-Bacterial Agents (Antibiotics)IBA
05/2024 - 12/2012
10Reactive Oxygen Species (Oxygen Radicals)IBA
01/2024 - 01/2018
10GoldIBA
10/2023 - 07/2016
9LipidsIBA
04/2024 - 09/2014
9CytokinesIBA
01/2024 - 07/2014
8Interleukin-6 (Interleukin 6)IBA
12/2023 - 12/2014
7Triglycerides (Triacylglycerol)IBA
02/2024 - 01/2018
7EnzymesIBA
12/2023 - 01/2015
7omega-Chloroacetophenone (Mace)IBA
01/2023 - 01/2014
6Therapeutic UsesIBA
04/2024 - 01/2019
6DNA (Deoxyribonucleic Acid)IBA
10/2023 - 01/2015
5Brain Natriuretic Peptide (Natrecor)FDA Link
03/2024 - 09/2013
5ErbB Receptors (EGF Receptor)IBA
11/2023 - 01/2016
5Aspartate Aminotransferases (Aspartate Transaminase)IBA
11/2023 - 01/2017
5Indicators and Reagents (Reagents)IBA
10/2023 - 02/2011
5Transcription Factors (Transcription Factor)IBA
10/2023 - 04/2015
5Peptides (Polypeptides)IBA
11/2022 - 11/2011
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2022 - 08/2014
5AcidsIBA
08/2022 - 01/2015
5Small Interfering RNA (siRNA)IBA
01/2022 - 06/2012
5Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
03/2021 - 01/2014
4LigandsIBA
05/2024 - 01/2020
4CreatinineIBA
02/2024 - 09/2013
4AlbuminsIBA
02/2024 - 01/2020
4Uric Acid (Urate)IBA
01/2024 - 06/2012
4Metal-Organic FrameworksIBA
01/2024 - 01/2020
4Alanine Transaminase (SGPT)IBA
11/2023 - 01/2017
4Oxygen (Dioxygen)IBA
04/2023 - 08/2016
41-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2023 - 01/2016
4Phosphotransferases (Kinase)IBA
01/2023 - 04/2015
4SodiumIBA
10/2022 - 09/2015
4Angiotensin IIIBA
07/2022 - 01/2013
4Caspase 3 (Caspase-3)IBA
01/2022 - 09/2014

Therapy/Procedure

57Therapeutics
04/2024 - 12/2012
15Drug Therapy (Chemotherapy)
04/2024 - 04/2015
11Percutaneous Coronary Intervention
10/2023 - 01/2014
7Immunotherapy
04/2024 - 12/2021
7Transplantation
10/2023 - 08/2014
6Radiotherapy
10/2023 - 01/2019
6Chinese Traditional Medicine (Traditional Chinese Medicine)
01/2023 - 10/2018
5Injections
01/2024 - 01/2021
5Aftercare (After-Treatment)
01/2024 - 04/2014
5Length of Stay
01/2024 - 11/2019
4Catheters
01/2024 - 01/2019
4Neoadjuvant Therapy
11/2022 - 08/2018
4Photochemotherapy (Photodynamic Therapy)
08/2022 - 01/2016