Hermann Tenor Selected Research

African Trypanosomiasis (Nagana)

10/2018	Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
4/2016	Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
3/2013	Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

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Hermann Tenor Research Topics

Disease

9	Chronic Obstructive Pulmonary Disease (COPD) 08/2021 - 05/2010
3	Wounds and Injuries (Trauma) 10/2022 - 10/2020
3	African Trypanosomiasis (Nagana) 10/2018 - 03/2013
2	Inflammation (Inflammations) 01/2014 - 01/2012
2	Lung Diseases (Lung Disease) 10/2013 - 05/2010
2	Asthma (Bronchial Asthma) 01/2011 - 05/2010
2	Pulmonary Hypertension 08/2010 - 07/2009
1	Cicatrix (Scar) 01/2021
1	digital ulcers 10/2020
1	Systemic Scleroderma (Systemic Sclerosis) 10/2020
1	Trypanosomiasis 10/2018
1	Disease Progression 11/2016
1	Bullous Pemphigoid (Pemphigoid) 11/2016
1	Infections 07/2013
1	Fibrosis (Cirrhosis) 01/2013
1	Communicable Diseases (Infectious Diseases) 07/2012
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2011
1	Pneumonia (Pneumonitis) 08/2010
1	Idiopathic Pulmonary Fibrosis 05/2010
1	Right Ventricular Hypertrophy 07/2009
1	Vascular Remodeling 07/2009
1	Hypertension (High Blood Pressure) 07/2009
1	Hypoxia (Hypoxemia) 07/2009
1	Malaria 12/2008
1	Sepsis (Septicemia) 05/2005
1	Pulmonary Edema 05/2005
1	Edema (Dropsy) 05/2005
1	Osteoarthritis 02/2002

Drug/Important Bio-Agent (IBA)

10	RoflumilastIBA 08/2021 - 07/2009
6	Phosphodiesterase 4 InhibitorsIBA 01/2013 - 02/2002
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2022 - 02/2002
3	Phosphodiesterase 5 InhibitorsIBA 10/2022 - 10/2020
3	EnzymesIBA 10/2020 - 07/2012
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2016 - 02/2002
3	roflumilast N-oxideIBA 01/2016 - 01/2012
3	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2013 - 02/2002
2	diethylstilbestrol monophosphate (PDES)IBA 10/2018 - 12/2008
2	CytokinesIBA 01/2014 - 05/2005
2	SmokeIBA 01/2014 - 08/2010
1	HydrogelsIBA 10/2022
1	Nitric Oxide DonorsIBA 01/2021
1	CollagenIBA 01/2021
1	Immunoglobulin G (IgG)IBA 11/2016
1	AutoantibodiesIBA 11/2016
1	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2016
1	AntigensIBA 11/2016
1	AutoantigensIBA 11/2016
1	Collagen Type VIIIBA 11/2016
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2013
1	Cyclic NucleotidesIBA 03/2013
1	Formoterol Fumarate (Oxis)FDA Link 01/2013
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2013
1	6- ((3- ((dimethylamino)carbonyl)phenyl)sulfonyl)- 8- methyl- 4- ((3- methyloxyphenyl)amino)- 3- quinolinecarboxamideIBA 01/2011
1	apremilastIBA 01/2011
1	GasesIBA 08/2010
1	GoldIBA 08/2010
1	SteroidsIBA 08/2010
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/2010
1	Interleukin-1beta (Interleukin 1 beta)IBA 05/2010
1	benzamideIBA 07/2009
1	MonocrotalineIBA 07/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2005
1	Thrombin FDA Link 05/2005
1	AlbuminsIBA 05/2005
1	IsoenzymesIBA 02/2002

Therapy/Procedure

4	Therapeutics 08/2021 - 05/2010