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Melissa J Spencer Selected Research

Dystrophin

8/2023Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD.
11/2022Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models.
11/2021Molecular and cellular basis of genetically inherited skeletal muscle disorders.
10/2019Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases.
6/2018Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse.
1/2018ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs.
10/2017Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury.
4/2016A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells.
12/2012Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy.
4/2011Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice.
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Melissa J Spencer Research Topics

Disease

14Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
08/2023 - 10/2002
11Muscular Dystrophies (Muscular Dystrophy)
11/2021 - 08/2003
10Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
01/2020 - 10/2005
8Limb-girdle muscular dystrophy type 2A
09/2011 - 10/2003
4Muscular Diseases (Myopathy)
05/2024 - 04/2009
3Atrophy
01/2018 - 08/2005
3Inflammation (Inflammations)
01/2016 - 10/2014
3Limb-girdle muscular dystrophy type 2H
05/2012 - 11/2005
2Hypertrophy
08/2023 - 01/2020
1Wasting Syndrome (Wasting Disease)
11/2022
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2019
1Colonic Neoplasms (Colon Cancer)
01/2019
1Neoplasms (Cancer)
01/2019
1Disease Progression
01/2016
1Malignant Hyperthermia
12/2012
1Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl)
10/2011
1Autolysis
09/2011
1Mitochondrial Diseases (Mitochondrial Disease)
09/2009
1Fibrosis (Cirrhosis)
06/2009
1Schizophrenia (Dementia Praecox)
05/2006
1Hermanski-Pudlak Syndrome (Hermansky-Pudlak Syndrome)
05/2006
1Distal Myopathies (Distal Muscular Dystrophy)
10/2005
1Myositis (Idiopathic Inflammatory Myopathies)
10/2005
1Hypercapnia
09/2003
1Muscular Atrophy (Muscle Atrophy)
12/2002
1Necrosis
10/2002

Drug/Important Bio-Agent (IBA)

12DystrophinIBA
08/2023 - 10/2002
11CalpainIBA
01/2018 - 10/2002
8Proteins (Proteins, Gene)FDA Link
11/2022 - 10/2003
6Peptide Hydrolases (Proteases)FDA Link
09/2011 - 10/2002
4OsteopontinIBA
10/2017 - 06/2009
4Cysteine Proteases (Cysteine Protease)IBA
09/2009 - 08/2005
3Carrier Proteins (Binding Protein)IBA
10/2017 - 05/2006
3Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
05/2015 - 04/2009
3ConnectinIBA
09/2011 - 07/2004
2CalciumIBA
11/2006 - 10/2002
1protein O-mannose beta-1,2-N-acetylglucosaminyltransferaseIBA
05/2024
1Galectin 3 (LGALS3)IBA
04/2023
1Muscle Proteins (Muscle Protein)IBA
11/2021
1UtrophinIBA
12/2020
1AMP-Activated Protein KinasesIBA
01/2020
1MyostatinIBA
01/2020
1Superoxide Dismutase-1IBA
01/2019
1PolymersIBA
01/2019
1Interleukin-12 (IL 12)IBA
01/2019
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2017
1Protein SIBA
03/2017
1Immunologic Factors (Immunomodulators)IBA
01/2016
1LuciferasesIBA
01/2015
1Interleukin-10 (Interleukin 10)IBA
10/2014
1InterferonsIBA
10/2014
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2014
1Dantrolene (Dantrium)FDA LinkGeneric
12/2012
1Glycoproteins (Glycoprotein)IBA
12/2012
1Messenger RNA (mRNA)IBA
12/2012
1Tripartite Motif ProteinsIBA
10/2011
1Cysteine (L-Cysteine)FDA Link
09/2011
1Creatine Kinase (Creatine Phosphokinase)IBA
01/2011
1atalurenIBA
10/2009
1Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA
09/2009
1Transforming Growth Factor beta (TGF-beta)IBA
06/2009
1DysbindinIBA
05/2006
1dystrobrevinIBA
05/2006
1UbiquitinIBA
11/2005
1Myosins (Myosin)IBA
11/2005
1Ligases (Synthetase)IBA
11/2005
1Ubiquitinated ProteinsIBA
08/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2003
1calpastatinIBA
12/2002

Therapy/Procedure

3Therapeutics
01/2017 - 08/2003
1Precision Medicine
10/2009