Joshua A Sommers Selected Research

Proteins (Proteins, Gene)

12/2023	The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
8/2023	PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES.
1/2023	Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions.
1/2019	Cellular Assays to Study the Functional Importance of Human DNA Repair Helicases.
4/2015	Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
10/2014	DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
7/2014	Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
6/2012	The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
11/2010	Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
7/2009	FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.

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Joshua A Sommers Research Topics

Disease

14	Genomic Instability 01/2022 - 10/2002
13	Neoplasms (Cancer) 12/2023 - 07/2005
9	Werner Syndrome (Werner's Syndrome) 08/2023 - 06/2003
8	Fanconi Anemia (Fanconi's Anemia) 04/2015 - 11/2010
7	Bloom Syndrome 04/2015 - 03/2004
6	Premature Aging 08/2023 - 08/2004
5	Breast Neoplasms (Breast Cancer) 11/2015 - 07/2005
4	Chromosomal Instability (Chromosome Stability) 11/2021 - 09/2013
4	Inborn Genetic Diseases (Disease, Hereditary) 07/2016 - 07/2005
2	Cockayne Syndrome (Syndrome, Cockayne) 04/2015 - 09/2013
2	Chromosome Breakage 07/2014 - 01/2013
2	Xeroderma Pigmentosum (Kaposi's Disease) 01/2014 - 09/2013
2	Carcinogenesis 07/2009 - 01/2006
1	COVID-19 01/2023
1	Ichthyosis (Xeroderma) 01/2022
1	Microsatellite Instability 10/2020
1	Ovarian Neoplasms (Ovarian Cancer) 01/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2014
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 10/2013
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 09/2013
1	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2013
1	Bone Marrow Failure Disorders 09/2013
1	Chromosome Aberrations (Chromosome Abnormalities) 09/2013
1	Microcephaly 01/2013
1	Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson) 07/2005

Drug/Important Bio-Agent (IBA)

21	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 10/2002
15	Proteins (Proteins, Gene)FDA Link 12/2023 - 06/2003
10	DNA HelicasesIBA 01/2022 - 08/2004
6	RecQ HelicasesIBA 11/2015 - 03/2004
4	A-Form DNA (A-DNA)IBA 01/2020 - 10/2002
4	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/2014 - 01/2013
4	Exonucleases (3' 5' Exonuclease)IBA 07/2010 - 10/2002
3	EnzymesIBA 10/2016 - 01/2005
3	Flap EndonucleasesIBA 01/2005 - 10/2002
2	RNA (Ribonucleic Acid)IBA 12/2023 - 04/2015
2	Mitochondrial DNA (mtDNA)IBA 07/2016 - 10/2014
2	DNA-Binding Proteins (DNA Binding Protein)IBA 07/2014 - 08/2005
2	Replication Protein AIBA 07/2014 - 08/2005
2	NSC 617145IBA 10/2013 - 09/2013
2	IronIBA 09/2013 - 01/2013
2	SulfurIBA 09/2013 - 01/2013
2	Werner Syndrome HelicaseIBA 09/2013 - 01/2011
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 09/2013 - 01/2006
2	Bloom syndrome proteinIBA 02/2011 - 03/2004
1	ZincIBA 01/2022
1	ChromatinIBA 11/2021
1	Biomarkers (Surrogate Marker)IBA 10/2020
1	UbiquitinIBA 04/2015
1	Ligases (Synthetase)IBA 04/2015
1	DNA-Activated Protein KinaseIBA 09/2013
1	maleimideIBA 01/2011
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2011
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2011
1	1-(propoxymethyl)maleimideIBA 01/2011
1	telomestatinIBA 01/2011
1	Staphylococcal Protein A (Protein A)IBA 03/2004
1	EndonucleasesIBA 03/2004
1	human EXO1 proteinIBA 06/2003

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 10/2013