Palwinder Singh Selected Research

Inflammation (Inflammations)

1/2022	Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2.
1/2020	Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
1/2020	Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme.
11/2019	Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation.
8/2019	Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.
5/2018	Design and Synthesis of Aza-/Oxa Heterocycle-Based Conjugates as Novel Anti-Inflammatory Agents Targeting Cyclooxygenase-2.
1/2018	Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.
1/2018	Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.
1/2016	Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.
8/2015	Triblock Conjugates: Identification of a Highly Potent Antiinflammatory Agent.

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Palwinder Singh Research Topics

Disease

20	Neoplasms (Cancer) 12/2023 - 12/2006
11	Inflammation (Inflammations) 01/2022 - 01/2008
5	Pain (Aches) 01/2021 - 06/2015
4	Hyperalgesia 02/2020 - 08/2019
2	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 02/2015
2	Poisoning 01/2019 - 08/2011
1	Breast Diseases (Breast Disease) 12/2023
1	Edema (Dropsy) 02/2020
1	Dehydration (Water Stress) 01/2020
1	Malaria 10/2019
1	Neuralgia (Stump Neuralgia) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Tuberculosis (Tuberculoses) 11/2016
1	Bronchiolitis 01/2016
1	Otitis Media 01/2016
1	Bronchopneumonia 01/2016
1	Gastroenteritis 01/2016
1	Skin Diseases (Skin Disease) 01/2016
1	Glioma (Gliomas) 09/2015
1	beta-Thalassemia (Cooley's Anemia) 01/2010
1	Candidiasis (Moniliasis) 06/2009

Drug/Important Bio-Agent (IBA)

7	Formaldehyde (Formol)FDA Link 02/2020 - 05/2018
6	Acetic Acid (Vinegar)FDA LinkGeneric 02/2020 - 01/2018
6	EnzymesIBA 11/2019 - 01/2008
5	indoleIBA 01/2021 - 03/2007
5	CarrageenanIBA 02/2020 - 01/2016
4	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2022 - 05/2010
3	Analgesics (Analgesic Drugs)IBA 10/2019 - 08/2015
3	CytokinesIBA 10/2019 - 01/2019
3	acridoneIBA 01/2019 - 03/2009
3	Capsaicin (Zostrix)FDA Link 01/2016 - 06/2015
3	Phosphorylases (Glucan Phosphorylase)IBA 04/2011 - 04/2008
3	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 04/2011 - 04/2008
3	Type II DNA Topoisomerases (Topoisomerase II)IBA 04/2011 - 04/2008
3	Thymidylate SynthaseIBA 04/2011 - 04/2008
3	pyrimidineIBA 11/2010 - 12/2006
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2022 - 01/2020
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 08/2019
2	piperidineIBA 01/2020 - 12/2006
2	osthol (osthole)IBA 10/2019 - 08/2019
2	AcridonesIBA 10/2019 - 03/2009
2	5-MethoxypsoralenIBA 08/2019 - 01/2019
2	Cyanides (Isocyanides)IBA 01/2019 - 08/2011
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2019 - 01/2018
2	Growth InhibitorsIBA 01/2018 - 05/2010
2	Dextrans (Dextran)FDA Link 08/2015 - 06/2015
1	Peptides (Polypeptides)IBA 03/2024
1	Scopolamine (Hyoscine)FDA Link 03/2024
1	Aromatase (CYP19)IBA 12/2023
1	Estrogen ReceptorsIBA 12/2023
1	Reserpine (Serpasil)FDA Link 01/2021
1	aegelineIBA 01/2021
1	Monoamine Oxidase (MAO)IBA 01/2021
1	imperatorinIBA 02/2020
1	trans-sodium crocetinate (crocetin)IBA 01/2020
1	TriazinesIBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	Arachidonic Acid (Vitamin F)IBA 11/2019
1	Proline (L-Proline)FDA Link 11/2019
1	Proteins (Proteins, Gene)FDA Link 10/2019
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 10/2019
1	Furocoumarins (Furanocoumarins)IBA 08/2019
1	2-oxindole (oxindole)IBA 01/2019
1	Heme (Haem)IBA 01/2019
1	PyrrolesIBA 01/2019
1	Vincristine (Oncovin)FDA LinkGeneric 01/2019
1	Sunitinib (Sutent)FDA Link 01/2018
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	Antimalarials (Antimalarial Agents)IBA 11/2016
1	compound 30IBA 01/2016
1	TubulinIBA 09/2015
1	Amino Acids FDA Link 09/2015
1	AcridinesIBA 09/2015
1	mortalinIBA 09/2015
1	Diclofenac (SR 38)FDA LinkGeneric 06/2015
1	Amyloid beta-PeptidesIBA 02/2015
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 02/2015
1	syringaldehyde (SYAL)IBA 07/2012
1	Trimethoprim (Proloprim)FDA LinkGeneric 07/2012
1	AntidotesIBA 08/2011
1	pyrazoleIBA 11/2010
1	Cytotoxins (Cytolysins)IBA 11/2010
1	ChromonesIBA 11/2010
1	tributyltinIBA 09/2010
1	TabletsIBA 01/2010
1	AminesIBA 03/2009
1	Amsacrine (AMSA)IBA 03/2009
1	Hydroxyl RadicalIBA 03/2009
1	Propafenone (Rythmol)FDA LinkGeneric 03/2009
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2008
1	LigandsIBA 04/2008
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 04/2008
1	MutagensIBA 04/2008
1	4-Butyrolactone (gamma Butyrolactone)IBA 01/2008

Therapy/Procedure

3	Analgesia 01/2020 - 01/2018
1	Length of Stay 01/2016
1	Blood Transfusion (Blood Transfusions) 01/2010
1	Therapeutics 06/2009