John Simes Selected Research

Stomach Neoplasms (Stomach Cancer)

8/2017	TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG.
10/2016	Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.
7/2015	TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG).

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John Simes Research Topics

Disease

32	Neoplasms (Cancer) 05/2024 - 12/2003
22	Myocardial Infarction 05/2024 - 01/2002
19	Coronary Disease (Coronary Heart Disease) 01/2022 - 04/2003
16	Stroke (Strokes) 05/2024 - 04/2003
15	Cardiovascular Diseases (Cardiovascular Disease) 05/2024 - 07/2005
15	Colorectal Neoplasms (Colorectal Cancer) 01/2024 - 09/2009
12	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 11/2011
10	Acute Coronary Syndrome 01/2022 - 01/2002
6	Adenocarcinoma 01/2023 - 03/2007
6	Unstable Angina 01/2022 - 04/2003
5	Chronic Renal Insufficiency 01/2022 - 09/2004
5	Hypertension (High Blood Pressure) 01/2022 - 12/2009
5	Breast Neoplasms (Breast Cancer) 03/2016 - 01/2006
4	Disease Progression 09/2023 - 10/2016
4	Nausea 12/2018 - 09/2006
4	Venous Thromboembolism 01/2018 - 11/2012
3	Vascular Diseases (Vascular Disease) 01/2018 - 11/2016
3	Heart Failure 12/2017 - 01/2009
3	Diabetes Mellitus 12/2017 - 11/2016
3	Stomach Neoplasms (Stomach Cancer) 08/2017 - 07/2015
3	Type 2 Diabetes Mellitus (MODY) 11/2016 - 01/2009
3	Hemorrhage 09/2014 - 01/2002
2	Rhabdomyolysis 05/2024 - 11/2016
2	Muscular Diseases (Myopathy) 05/2024 - 11/2016
2	Glioma (Gliomas) 09/2023 - 11/2018
2	Pancreatic Neoplasms (Pancreatic Cancer) 08/2021 - 05/2015
2	Carcinoma (Carcinomatosis) 01/2021 - 03/2007
2	Head and Neck Neoplasms (Head and Neck Cancer) 01/2021 - 01/2019
2	Vomiting 12/2018 - 06/2015
2	Fatigue 01/2018 - 09/2006
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2018 - 02/2004
2	Exanthema (Rash) 07/2014 - 09/2006
2	Diabetes Complications 03/2012 - 01/2009
1	Renal Insufficiency (Renal Failure) 05/2022
1	Deafness (Deaf Mutism) 01/2022
1	Cerebral Palsy (Spastic Diplegia) 01/2022
1	Sarcopenia 08/2021

Drug/Important Bio-Agent (IBA)

20	Pravastatin (Pravachol)FDA LinkGeneric 01/2022 - 04/2003
19	LipidsIBA 01/2022 - 04/2003
13	Biomarkers (Surrogate Marker)IBA 01/2024 - 03/2014
11	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2024 - 09/2004
9	CholesterolIBA 05/2024 - 04/2003
9	Cetuximab (Erbitux)FDA Link 01/2019 - 09/2009
8	Bevacizumab (Avastin)FDA Link 01/2022 - 06/2014
8	LDL CholesterolIBA 10/2018 - 05/2004
5	ErbB Receptors (EGF Receptor)IBA 01/2019 - 09/2009
4	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2023 - 11/2012
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2014
4	Temozolomide (Temodar)FDA LinkGeneric 10/2021 - 11/2011
4	Carboplatin (JM8)FDA LinkGeneric 12/2019 - 11/2015
3	oxidized low density lipoproteinIBA 05/2024 - 05/2004
3	regorafenibIBA 02/2023 - 10/2016
3	fibrin fragment D (D-dimer)IBA 01/2019 - 12/2017
3	HDL CholesterolIBA 10/2018 - 05/2004
3	Troponin IIBA 01/2018 - 02/2014
3	Monoclonal AntibodiesIBA 01/2016 - 10/2010
3	Fenofibrate (CiL)FDA LinkGeneric 03/2012 - 01/2009
2	durvalumabIBA 01/2023 - 01/2023
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 12/2017
2	Cystatin CIBA 01/2022 - 12/2017
2	CreatinineIBA 01/2022 - 09/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 10/2016
2	Proteins (Proteins, Gene)FDA Link 12/2019 - 12/2015
2	depatuxizumab mafodotinIBA 01/2019 - 12/2017
2	Irinotecan (Camptosar)FDA LinkGeneric 12/2018 - 01/2016
2	Lipoprotein(a)IBA 10/2018 - 12/2013
2	C-Reactive ProteinIBA 01/2018 - 12/2017
2	Fluorouracil (Carac)FDA LinkGeneric 08/2017 - 07/2015
2	Cisplatin (Platino)FDA LinkGeneric 08/2017 - 07/2015
2	Epirubicin (Ellence)FDA LinkGeneric 08/2017 - 07/2015
2	Epidermal Growth Factor (EGF)IBA 03/2016 - 12/2015
2	AnticoagulantsIBA 09/2014 - 11/2012
1	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2023
1	Acetazolamide (Diamox)FDA LinkGeneric 09/2023
1	Dexamethasone (Maxidex)FDA LinkGeneric 09/2023
1	olaparibIBA 01/2023
1	tremelimumabIBA 01/2023
1	SDMIBA 01/2022
1	Trastuzumab (Herceptin)FDA Link 01/2022
1	Capecitabine (Xeloda)FDA Link 01/2022
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2022
1	MethyltransferasesIBA 10/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2021
1	veliparibIBA 10/2021
1	folfirinoxIBA 08/2021
1	mesoglycanIBA 01/2021

Therapy/Procedure

31	Therapeutics 01/2023 - 01/2002
19	Drug Therapy (Chemotherapy) 01/2023 - 09/2006
5	Radiotherapy 10/2021 - 01/2006
5	Secondary Prevention 12/2018 - 05/2004
4	Chemoradiotherapy 01/2021 - 03/2007
2	Neoadjuvant Therapy 01/2023 - 03/2007
2	Immunotherapy 01/2022 - 01/2021
2	Combination Drug Therapy (Combination Chemotherapy) 07/2013 - 04/2009
2	Thrombolytic Therapy 02/2006 - 02/2004
2	Percutaneous Coronary Intervention 11/2005 - 01/2005
1	Kidney Transplantation 05/2022
1	Peritoneal Dialysis 05/2022
1	Cochlear Implants (Cochlear Implant) 01/2022
1	Hearing Aids (Hearing Aid) 01/2022