Hideo Shimizu Selected Research

Inflammation (Inflammations)

12/2018	Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.
1/2018	IGF Binding Protein-5 Induces Cell Senescence.
1/2018	Source of Chronic Inflammation in Aging.
1/2018	Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.
12/2017	Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence.
12/2017	Inhibition of Aneurysm Progression by Direct Renin Inhibition in a Rabbit Model.
11/2016	A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke.

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Hideo Shimizu Research Topics

Disease

7	Breast Neoplasms (Breast Cancer) 10/2021 - 08/2011
7	Inflammation (Inflammations) 12/2018 - 11/2016
7	Atherosclerosis 03/2018 - 02/2004
7	Osteoporosis 07/2014 - 07/2008
6	Neoplasms (Cancer) 05/2018 - 05/2010
4	Bone Fractures (Bone Fracture) 11/2014 - 07/2008
4	Vascular Calcification 07/2014 - 08/2010
3	Infections 04/2023 - 03/2009
3	Ischemic Stroke 12/2018 - 11/2016
3	Hypertension (High Blood Pressure) 05/2009 - 07/2005
2	Rheumatoid Arthritis 01/2021 - 09/2012
2	Ischemia 03/2018 - 08/2007
2	Carcinogenesis 01/2014 - 08/2011
2	Hyperplasia 01/2014 - 05/2010
2	Fibrosis (Cirrhosis) 01/2014 - 01/2012
2	Metabolic Diseases (Metabolic Disease) 09/2012 - 09/2009
2	Fatty Liver 01/2012 - 09/2008
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2012 - 10/2010
2	Alcoholic Fatty Liver 01/2012 - 10/2010
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2012 - 10/2010
2	Neoplasm Metastasis (Metastasis) 08/2011 - 03/2004
2	Body Weight (Weight, Body) 03/2009 - 09/2008
1	COVID-19 04/2023
1	Frailty 01/2023
1	Intellectual Disability (Idiocy) 01/2023
1	Sarcopenia 01/2023
1	Fragile X Syndrome (Martin Bell Syndrome) 01/2023
1	Lung Diseases (Lung Disease) 01/2021
1	Arthritis (Polyarthritis) 01/2021
1	Experimental Arthritis 01/2021
1	Stroke (Strokes) 12/2018
1	Myocardial Infarction 03/2018
1	Brain Ischemia (Cerebral Ischemia) 01/2018
1	Infarction (Infarctions) 01/2018
1	Atherosclerotic Plaque (Atheroma) 12/2017
1	Abdominal Aortic Aneurysm 12/2017
1	Aortic Aneurysm (Aneurysm, Aortic) 12/2017
1	Aneurysm (Aneurysms) 12/2017
1	Brain Injuries (Brain Injury) 11/2016

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2010
4	Hormones (Hormone)IBA 10/2021 - 11/2014
4	Angiotensin IIIBA 12/2017 - 07/2008
3	Peptides (Polypeptides)IBA 12/2018 - 11/2016
3	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2018 - 11/2016
3	LipidsIBA 03/2018 - 03/2009
3	LigandsIBA 12/2017 - 06/2013
2	VaccinesIBA 04/2023 - 04/2023
2	Messenger RNA (mRNA)IBA 01/2023 - 08/2010
2	Therapeutic UsesIBA 12/2018 - 01/2018
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2018 - 02/2004
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 09/2009
2	Insulin-Like Growth Factor Binding Protein 5IBA 01/2018 - 12/2017
2	ReninIBA 12/2017 - 06/2013
2	Phenobarbital (Luminal)FDA Link 04/2015 - 07/2014
2	Tumor Biomarkers (Tumor Markers)IBA 11/2014 - 03/2004
2	diisopropanolnitrosamineIBA 01/2014 - 05/2010
2	Antihypertensive Agents (Antihypertensives)IBA 01/2012 - 07/2008
2	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2012 - 07/2005
2	Choline (Choline Chloride)IBA 01/2012 - 10/2010
2	Methionine (L-Methionine)FDA Link 01/2012 - 10/2010
2	Insulin (Novolin)FDA Link 09/2011 - 05/2009
2	Telmisartan (Micardis)FDA Link 10/2010 - 09/2008
2	Estrogens (Estrogen)FDA Link 08/2010 - 07/2010
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 09/2009 - 07/2008
1	COVID-19 VaccinesIBA 04/2023
1	Immunoglobulin G (IgG)IBA 04/2023
1	CreatinineIBA 01/2023
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2023
1	Cystatin CIBA 01/2023
1	UbiquitinIBA 01/2023
1	C-Reactive ProteinIBA 01/2021
1	palbociclibIBA 01/2021
1	Cyclin-Dependent Kinase 4IBA 01/2021
1	Fulvestrant (Faslodex)FDA Link 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 01/2021
1	Protein Sorting Signals (Signal Peptide)IBA 12/2018
1	eribulin FDA Link 10/2018
1	Everolimus FDA Link 05/2018
1	CytokinesIBA 01/2018
1	Fluorescein-5-isothiocyanate (FITC)IBA 01/2018
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2018
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2018
1	LDL CholesterolIBA 01/2018
1	Factor Xa (Coagulation Factor Xa)IBA 12/2017
1	ChemokinesIBA 12/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 12/2017
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2017
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 12/2017
1	Angiotensin IIBA 12/2017
1	aliskiren FDA Link 12/2017
1	Estrogen ReceptorsIBA 10/2015

Therapy/Procedure

5	Therapeutics 12/2018 - 09/2009
2	Transcutaneous Electric Nerve Stimulation (TENS) 04/2023 - 04/2023
2	Ovariectomy (Oophorectomy) 08/2010 - 07/2010
2	Estrogen Replacement Therapy 08/2010 - 07/2010
1	Neoadjuvant Therapy 10/2021
1	Surgical Amputation (Amputations) 03/2018
1	Intravenous Injections 01/2018
1	Carotid Endarterectomy 12/2017