Neil S Sheerin Selected Research

Fibrosis (Cirrhosis)

12/2019	Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy.
1/2019	Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction.
1/2019	Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation.
2/2016	Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
1/2016	Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.
12/2015	Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.

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Neil S Sheerin Research Topics

Disease

8	Infections 01/2023 - 10/2004
6	Chronic Kidney Failure (Chronic Renal Failure) 10/2023 - 01/2008
6	Atypical Hemolytic Uremic Syndrome 10/2023 - 11/2017
6	Fibrosis (Cirrhosis) 12/2019 - 12/2015
5	Thrombotic Microangiopathies 10/2023 - 10/2011
5	Reperfusion Injury 07/2023 - 12/2013
5	Inflammation (Inflammations) 01/2023 - 01/2017
5	Kidney Diseases (Kidney Disease) 01/2023 - 01/2017
5	Renal Insufficiency (Renal Failure) 04/2020 - 01/2008
3	Acute Kidney Injury (Acute Renal Failure) 12/2020 - 01/2016
3	Liver Diseases (Liver Disease) 04/2020 - 12/2015
3	Chronic Renal Insufficiency 01/2019 - 01/2008
3	Delayed Graft Function 01/2019 - 12/2013
2	Neoplasms (Cancer) 04/2020 - 01/2020
2	Lung Diseases (Lung Disease) 04/2020 - 01/2020
2	Peripheral Arterial Disease 04/2020 - 01/2020
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 04/2020 - 01/2020
2	Hematologic Diseases (Blood Diseases) 04/2020 - 01/2020
2	Obesity 04/2020 - 01/2020
2	Meningococcal Infections 10/2019 - 12/2017
2	Proteinuria 03/2009 - 04/2008
2	Glomerulonephritis 05/2007 - 03/2006
1	Pre-Eclampsia (Preeclampsia) 06/2023
1	Fatigue 05/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 11/2020
1	Diarrhea 10/2020
1	Weight Loss (Weight Reduction) 10/2020
1	Acute-Phase Reaction 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Brain Edema (Cerebral Edema) 01/2020
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2020
1	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2020
1	Thrombotic Thrombocytopenic Purpura 01/2019
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2019
1	Wounds and Injuries (Trauma) 01/2018
1	Dizziness (Lightheadedness) 01/2008
1	Psychotic Disorders (Schizoaffective Disorder) 01/2008
1	Headache (Headaches) 01/2008
1	Nausea 01/2008
1	Myoclonus (Nocturnal Myoclonus) 01/2008
1	Reinfection 08/2006

Drug/Important Bio-Agent (IBA)

12	Complement System Proteins (Complement)IBA 10/2023 - 03/2006
7	eculizumab FDA Link 01/2023 - 10/2011
4	ChemokinesIBA 01/2023 - 01/2017
3	Complement Inactivating AgentsIBA 05/2022 - 04/2019
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2004
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 12/2013
2	MineralsIBA 04/2020 - 01/2020
2	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2019
2	pepstatin (pepstatin A)IBA 02/2016 - 01/2016
2	Peptide Hydrolases (Proteases)FDA Link 02/2016 - 01/2016
2	Cathepsin DIBA 02/2016 - 01/2016
2	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2009 - 04/2008
1	MineralocorticoidsIBA 10/2023
1	Inflammation MediatorsIBA 07/2023
1	Interleukin-8 (Interleukin 8)IBA 01/2023
1	ravulizumabIBA 05/2022
1	Insulin (Novolin)FDA Link 12/2020
1	Carbon Tetrachloride (Tetrachloromethane)IBA 11/2020
1	Diacylglycerol KinaseIBA 01/2020
1	chemotactic factor inactivatorIBA 01/2020
1	superoxide dismutase 2IBA 01/2020
1	AntioxidantsIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Complement Factor I (C3b Inactivator)IBA 01/2020
1	Heme Oxygenase-1IBA 01/2020
1	indium-bleomycinIBA 01/2019
1	thiamine triphosphorate (TTP)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	EnzymesIBA 01/2019
1	GlycosaminoglycansIBA 01/2019
1	Heparitin Sulfate (Heparan Sulfate)IBA 01/2019
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2019
1	CollagenIBA 01/2018
1	Extracellular Matrix ProteinsIBA 01/2018
1	Complement Factor H (Factor H)IBA 11/2017
1	AutoantibodiesIBA 11/2017
1	Mitochondrial DNA (mtDNA)IBA 01/2017
1	CreatinineIBA 04/2016
1	Chloroquine (Aralen)FDA LinkGeneric 02/2016
1	Deubiquitinating EnzymesIBA 12/2015
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 12/2015
1	LDN 57444IBA 12/2015
1	Immunoglobulin G (IgG)IBA 02/2008
1	AntibodiesIBA 02/2008
1	Immunoglobulin M (IgM)IBA 02/2008
1	Flecainide (Tambocor)FDA LinkGeneric 01/2008
1	ElementsIBA 05/2007
1	LigandsIBA 08/2006
1	Complement Receptors (Complement Receptor)IBA 08/2006
1	Antigen-Antibody Complex (Immune Complex)IBA 03/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2005
1	CoagulaseIBA 05/2005

Therapy/Procedure

8	Kidney Transplantation 01/2023 - 12/2013
6	Therapeutics 06/2023 - 05/2005
5	Transplantation 12/2020 - 12/2013
1	Renal Replacement Therapy (Therapies, Renal Replacement) 12/2020
1	Plasma Exchange 11/2017
1	Ligation 12/2015
1	Peritoneal Dialysis 05/2005