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Puja Sapra Selected Research

Therapeutics

1/2023Advances in antibody-based therapy in oncology.
1/2022Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade.
1/2021Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.
1/2019Combination Treatment with an Antibody-Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer.
11/2017A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.
1/2017Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia.
1/2017Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate.
2/2016Combining antibody-drug conjugates and immune-mediated cancer therapy: What to expect?
1/2016Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
9/2015Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions.
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Puja Sapra Research Topics

Disease

39Neoplasms (Cancer)
03/2024 - 02/2002
5Lymphoma (Lymphomas)
10/2015 - 12/2002
4Ovarian Neoplasms (Ovarian Cancer)
12/2019 - 09/2015
3Breast Neoplasms (Breast Cancer)
10/2020 - 09/2015
3Tics (Tic)
11/2017 - 01/2013
3Hypoxia (Hypoxemia)
09/2011 - 11/2008
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2021 - 01/2018
2Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 04/2008
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2017 - 01/2013
2Triple Negative Breast Neoplasms
11/2017 - 09/2015
2Neoplasm Metastasis (Metastasis)
11/2017 - 11/2008
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2017 - 10/2015
2Non-Hodgkin Lymphoma (Lymphosarcoma)
10/2015 - 10/2009
2Neuroblastoma
10/2010 - 01/2003
2B-Cell Lymphoma (Lymphoma, B Cell)
04/2004 - 02/2004
1Leukemia
01/2021
1Melanoma (Melanoma, Malignant)
01/2021
1Lung Neoplasms (Lung Cancer)
10/2020
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2020
1Ovarian Epithelial Carcinoma
01/2019
1Myocarditis (Carditis)
01/2019
1Stomach Neoplasms (Stomach Cancer)
01/2017
1Residual Neoplasm
01/2017
1Hematologic Neoplasms (Hematological Malignancy)
10/2015
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
10/2015
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
10/2015
1Prostatic Neoplasms (Prostate Cancer)
12/2011

Drug/Important Bio-Agent (IBA)

24Immunoconjugates (Immunoconjugate)IBA
01/2022 - 07/2005
6Monoclonal AntibodiesIBA
01/2023 - 02/2004
6AntigensIBA
01/2021 - 11/2012
5A1mcMMAFIBA
12/2019 - 01/2013
5Liposomes (Liposome)IBA
10/2005 - 02/2002
4auristatinIBA
01/2022 - 01/2016
4LigandsIBA
01/2021 - 02/2002
4Glycoproteins (Glycoprotein)IBA
12/2019 - 06/2015
4EZN-2208IBA
09/2011 - 03/2008
4Irinotecan (Camptosar)FDA LinkGeneric
09/2011 - 03/2008
4Doxorubicin (Adriamycin)FDA LinkGeneric
10/2010 - 01/2003
3Immune Checkpoint InhibitorsIBA
03/2024 - 02/2016
3Ado-Trastuzumab EmtansineIBA
10/2020 - 10/2013
3Antineoplastic Agents (Antineoplastics)IBA
06/2015 - 03/2008
3Immunoglobulin G (IgG)IBA
11/2012 - 02/2004
3Proteins (Proteins, Gene)FDA Link
12/2011 - 11/2008
3Messenger RNA (mRNA)IBA
12/2011 - 11/2008
3LuciferasesIBA
12/2011 - 10/2010
2Histones (Histone)IBA
01/2022 - 10/2010
2Neoplasm Antigens (Tumor Antigens)IBA
01/2021 - 11/2015
2Cysteine (L-Cysteine)FDA Link
10/2020 - 01/2017
2Carboplatin (JM8)FDA LinkGeneric
12/2019 - 01/2019
2AntibodiesIBA
10/2016 - 10/2010
2CalicheamicinsIBA
10/2015 - 09/2015
2Surface Antigens (Surface Antigen)IBA
09/2015 - 02/2004
2Transcription Factors (Transcription Factor)IBA
12/2011 - 11/2008
2Antisense OligonucleotidesIBA
12/2011 - 02/2010
2Topoisomerase I InhibitorsIBA
09/2011 - 10/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2011 - 10/2010
2Vincristine (Oncovin)FDA LinkGeneric
10/2010 - 02/2004
2ProdrugsIBA
10/2010 - 04/2008
2liposomal doxorubicin (Doxil)FDA Link
04/2004 - 02/2004
2Immunoglobulin Fab FragmentsIBA
02/2004 - 01/2003
1CytokinesIBA
03/2024
1Interleukin-12 (IL 12)IBA
03/2024
1AZD5305IBA
01/2023
1Extracellular Matrix ProteinsIBA
01/2022
1Biomarkers (Surrogate Marker)IBA
01/2022
1Fibronectins (Fibronectin)IBA
01/2022
1Enterotoxin ReceptorsIBA
01/2020
1PlatinumIBA
01/2019
1Gemtuzumab (Mylotarg)FDA Link
01/2018
1Valine (L-Valine)FDA Link
11/2017
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2017
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2017
1CitrullineIBA
11/2017
1Brentuximab VedotinIBA
01/2017
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2017
1Paclitaxel (Taxol)FDA LinkGeneric
01/2016
1Sialic Acid Binding Ig-like Lectin 2IBA
10/2015
1Inotuzumab OzogamicinIBA
10/2015
1Rituximab (Mabthera)FDA Link
10/2015
1PF-06647263IBA
09/2015
1Cadherins (E-Cadherin)IBA
09/2015
1ClaudinsIBA
09/2015
1Ephrin-A4 (Ephrin A4)IBA
09/2015
1DNA (Deoxyribonucleic Acid)IBA
09/2015
1trans-sodium crocetinate (crocetin)IBA
10/2013
1Immunoglobulins (Immunoglobulin)IBA
11/2012
1abirateroneIBA
12/2011
1Androgen Receptors (Androgen Receptor)IBA
12/2011
1Testosterone (Sustanon)FDA Link
12/2011
1AndrogensIBA
12/2011

Therapy/Procedure

16Therapeutics
01/2023 - 10/2005
5Drug Therapy (Chemotherapy)
01/2021 - 04/2004
3Injections
03/2008 - 02/2004
2Aftercare (After-Treatment)
11/2017 - 09/2011
1Immunotherapy
01/2020
1Induction Chemotherapy
01/2018
1Transplantation
11/2017
1Remission Induction
01/2017
1Combination Drug Therapy (Combination Chemotherapy)
01/2017
1Castration
12/2011