Jacob Raber Selected Research

Neoplasms (Cancer)

9/2023	Inhibition of Anaplastic Lymphoma Kinase (Alk) as Therapeutic Target to Improve Brain Function in Neurofibromatosis Type 1 (Nf1).
11/2022	Association of fall rate and functional status by APOE genotype in cancer survivors after exercise intervention.
1/2022	Long-term effects of pharmacological inhibition of anaplastic lymphoma kinase in neurofibromatosis 1 mutant mice.
1/2022	Infusion of etoposide in the CA1 disrupts hippocampal immediate early gene expression and hippocampus-dependent learning.
1/2022	Common cancer treatments targeting DNA double strand breaks affect long-term memory and relate to immediate early gene expression in a sex-dependent manner.
11/2021	Apolipoprotein E levels in the amygdala and prefrontal cortex predict relative regional brain volumes in irradiated Rhesus macaques.
1/2021	Amifostine (WR-2721) Mitigates Cognitive Injury Induced by Heavy Ion Radiation in Male Mice and Alters Behavior and Brain Connectivity.
11/2020	Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer.
2/2017	Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model.
1/2017	CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.

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Jacob Raber Research Topics

Disease

37	Cognitive Dysfunction 05/2024 - 06/2002
28	Alzheimer Disease (Alzheimer's Disease) 08/2023 - 06/2002
15	Neoplasms (Cancer) 09/2023 - 01/2010
9	Inflammation (Inflammations) 05/2024 - 06/2013
6	Dementia (Dementias) 09/2022 - 05/2006
6	Insulin Resistance 07/2022 - 01/2017
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2024 - 01/2016
5	Neurofibromatosis 1 (Neurofibromatosis Type I) 09/2023 - 01/2017
5	Neuroinflammatory Diseases 01/2023 - 07/2013
5	Wounds and Injuries (Trauma) 01/2022 - 01/2012
5	Body Weight (Weight, Body) 01/2022 - 01/2017
4	Parkinson Disease (Parkinson's Disease) 02/2024 - 01/2021
4	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 08/2023 - 09/2015
4	Obesity 01/2023 - 12/2018
4	AIDS-Related Complex (ARC) 01/2022 - 10/2006
4	Shock 06/2016 - 06/2011
4	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2015 - 05/2009
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 10/2007
3	Carcinogenesis 07/2022 - 01/2020
3	Anxiety Disorders (Anxiety Disorder) 04/2015 - 10/2010
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2023 - 02/2013
2	Fatigue 07/2023 - 09/2018
2	Disease Progression 09/2022 - 02/2013
2	Phenylketonurias (Phenylketonuria) 01/2022 - 01/2018
2	Memory Disorders (Memory Loss) 01/2017 - 06/2002
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2016 - 04/2014
2	Brain Injuries (Brain Injury) 01/2015 - 02/2013
2	Seizures (Absence Seizure) 08/2008 - 10/2006
2	Androgen-Insensitivity Syndrome (Testicular Feminization) 04/2008 - 02/2005
1	Colitis 02/2024
1	Neurodevelopmental Disorders 09/2023
1	Vascular System Injuries 01/2023
1	Trifunctional Protein Deficiency With Myopathy And Neuropathy 01/2023
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2023
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2023
1	Second Primary Neoplasms (Neoplasms, Second) 11/2022
1	Tyrosinemias (Tyrosinemia) 09/2022
1	Pathologic Constriction (Stenosis) 09/2021
1	Chest Pain (Chest Pains) 09/2021
1	Postoperative Cognitive Complications 01/2021

Drug/Important Bio-Agent (IBA)

22	Apolipoproteins E (ApoE)IBA 08/2023 - 03/2004
16	Apolipoprotein E4IBA 08/2023 - 06/2002
14	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2003
14	ApolipoproteinsIBA 01/2023 - 06/2002
10	Protein Isoforms (Isoforms)IBA 01/2023 - 12/2006
8	Apolipoprotein E3IBA 01/2021 - 06/2002
5	Anaplastic Lymphoma KinaseIBA 09/2023 - 01/2017
5	salicylhydroxamic acid (SHAM)IBA 01/2020 - 05/2009
5	Apolipoprotein E2IBA 01/2019 - 06/2002
4	Amyloid (Amyloid Fibrils)IBA 01/2023 - 08/2003
4	Insulin (Novolin)FDA Link 07/2022 - 07/2005
4	xanthohumolIBA 01/2022 - 12/2018
4	AndrogensIBA 03/2011 - 06/2002
3	CytokinesIBA 05/2024 - 02/2017
3	Biomarkers (Surrogate Marker)IBA 01/2023 - 09/2015
3	OxylipinsIBA 01/2023 - 01/2022
3	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 09/2018
3	metabotropic glutamate receptor 8IBA 01/2021 - 07/2005
3	Protons (Proton)IBA 01/2016 - 02/2015
2	Epoxide HydrolasesIBA 05/2024 - 07/2022
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2023 - 02/2017
2	LipidsIBA 09/2022 - 01/2021
2	DNA (Deoxyribonucleic Acid)IBA 07/2022 - 01/2022
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 01/2018
2	Glutamic Acid (Glutamate)FDA Link 01/2021 - 10/2010
2	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2015
2	alpha-SynucleinIBA 01/2021 - 01/2021
2	FlavonoidsIBA 01/2020 - 12/2018
2	SugarsIBA 01/2020 - 01/2019
2	CholesterolIBA 09/2018 - 02/2013
2	IonsIBA 06/2016 - 03/2012
2	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2016 - 10/2011
2	Eflornithine (Ornidyl)FDA Link 11/2014 - 01/2012
2	ChemokinesIBA 07/2013 - 06/2013
2	Histamine (Histamine Dihydrochloride)FDA Link 06/2011 - 10/2007
2	Androgen Receptors (Androgen Receptor)IBA 03/2011 - 02/2005
2	Cholinergic Agents (Cholinergics)IBA 01/2011 - 08/2008
2	Amyloid beta-PeptidesIBA 05/2006 - 08/2003
1	Benzoic Acid (Potassium Benzoate)FDA Link 05/2024
1	4- (4- (3- adamantan- 1- ylureido)cyclohexyloxy)benzoic acidIBA 05/2024
1	14,15-epoxy-5,8,11-eicosatrienoic acidIBA 05/2024
1	Glucosylceramidase (Glucocerebrosidase)IBA 02/2024
1	Dextran SulfateIBA 02/2024
1	Drinking WaterIBA 01/2024
1	Centella asiatica extractIBA 01/2024
1	AntioxidantsIBA 10/2023
1	Neurofibromin 1 (Neurofibromin)IBA 09/2023
1	KetonesIBA 01/2023
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2023
1	7-ketocholesterolIBA 01/2023
1	Tyrosine (L-Tyrosine)FDA Link 09/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 09/2022
1	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 01/2022
1	pegvaliaseIBA 01/2022
1	Etoposide (VP 16)FDA LinkGeneric 01/2022
1	regadenoson FDA Link 09/2021
1	Protein AggregatesIBA 01/2021

Therapy/Procedure

13	Therapeutics 01/2022 - 01/2010
2	Radiotherapy 11/2021 - 02/2017
2	Fat-Restricted Diet (Diet, Fat Restricted) 09/2018 - 01/2016