George Perry Selected Research

Copper

12/2016	Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?
4/2009	A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease.
1/2008	Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.
11/2007	Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron.
7/2004	Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
4/2004	Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species.
1/2004	Prion disease and Alzheimer's disease: pathogenic overlap.
3/2003	Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.
1/2002	The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.
1/2002	Alzheimer Disease and Oxidative Stress.

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George Perry Research Topics

Disease

265	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 01/2002
63	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 01/2002
48	Amyloid Plaque 03/2024 - 01/2002
34	Parkinson Disease (Parkinson's Disease) 03/2024 - 03/2002
28	Dementia (Dementias) 11/2023 - 01/2002
22	Cognitive Dysfunction 03/2024 - 05/2004
13	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 05/2002
13	Neuroblastoma 01/2019 - 03/2002
11	Inflammation (Inflammations) 08/2023 - 10/2005
10	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2023 - 03/2002
9	Disease Progression 12/2023 - 10/2004
9	Neoplasms (Cancer) 10/2023 - 07/2003
9	Tauopathies 01/2020 - 03/2002
8	Prion Diseases (Transmissible Spongiform Encephalopathies) 08/2010 - 04/2002
7	Hypoxia (Hypoxemia) 01/2010 - 01/2003
6	Stroke (Strokes) 01/2023 - 01/2002
6	Nervous System Diseases (Neurological Disorders) 01/2020 - 10/2006
5	Neuroinflammatory Diseases 03/2024 - 12/2009
5	Frontotemporal Dementia (Semantic Dementia) 12/2023 - 04/2008
4	Lewy Body Disease (Lewy Body Dementia) 01/2017 - 07/2009
3	Atrophy 04/2023 - 04/2007
3	Encephalitis (Encephalitis, Rasmussen) 01/2023 - 09/2003
3	Chronic Disease (Chronic Diseases) 01/2017 - 05/2009
3	Iron Overload 12/2016 - 09/2005
3	Hemorrhage 01/2016 - 11/2002
3	Infections 11/2013 - 05/2004
3	Pathologic Processes 02/2010 - 09/2002

Drug/Important Bio-Agent (IBA)

57	Amyloid beta-PeptidesIBA 01/2023 - 01/2002
56	Amyloid (Amyloid Fibrils)IBA 03/2024 - 07/2002
53	Proteins (Proteins, Gene)FDA Link 04/2023 - 01/2002
31	MetalsIBA 03/2024 - 01/2002
28	IronIBA 03/2024 - 01/2002
25	AntioxidantsIBA 01/2020 - 02/2002
23	tau Proteins (tau Protein)IBA 01/2024 - 03/2002
16	Peptides (Polypeptides)IBA 11/2023 - 04/2002
13	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 01/2002
13	Estrogens (Estrogen)FDA Link 01/2018 - 07/2003
13	Nucleic AcidsIBA 01/2018 - 03/2002
13	Free RadicalsIBA 01/2010 - 04/2002
12	RNA (Ribonucleic Acid)IBA 08/2023 - 03/2002
11	EnzymesIBA 01/2018 - 03/2003
10	GonadotropinsIBA 01/2018 - 11/2002
10	CopperIBA 12/2016 - 01/2002
9	Luteinizing Hormone (Lutropin)FDA LinkGeneric 12/2007 - 11/2002
8	LipidsIBA 03/2024 - 01/2005
7	AntibodiesIBA 01/2023 - 03/2005
7	Phosphotransferases (Kinase)IBA 01/2019 - 08/2006
7	Heme (Haem)IBA 01/2016 - 03/2003
7	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2010 - 09/2002
7	Heme Oxygenase-1IBA 01/2010 - 03/2003
7	Chelating AgentsIBA 01/2010 - 03/2003
6	Biomarkers (Surrogate Marker)IBA 07/2023 - 01/2010
6	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 10/2005
6	SteroidsIBA 01/2018 - 01/2004
6	Hormones (Hormone)IBA 09/2017 - 01/2004
6	Oxidants (Oxidizing Agents)IBA 12/2009 - 02/2002
5	DNA (Deoxyribonucleic Acid)IBA 08/2023 - 03/2002
5	Protein AggregatesIBA 08/2023 - 10/2003
5	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2020 - 02/2008
5	CholesterolIBA 01/2019 - 07/2002
5	Mitogen-Activated Protein KinasesIBA 01/2019 - 09/2002
5	Insulin (Novolin)FDA Link 12/2012 - 02/2005
5	Prion ProteinsIBA 01/2012 - 05/2004
4	lecanemabIBA 03/2024 - 01/2023
4	DNA-Binding Proteins (DNA Binding Protein)IBA 12/2023 - 02/2018
4	Neurotransmitter Agents (Neurotransmitter)IBA 08/2023 - 10/2005
4	Apolipoproteins E (ApoE)IBA 10/2021 - 01/2012
4	Neuroprotective AgentsIBA 01/2020 - 01/2010
4	SynucleinsIBA 12/2019 - 01/2011
4	Cholinergic Agents (Cholinergics)IBA 01/2019 - 04/2008
4	Leucine (L-Leucine)FDA Link 01/2018 - 11/2006
4	LeptinIBA 07/2015 - 01/2009
4	IonsIBA 08/2012 - 07/2002
4	8-hydroxyguanosineIBA 03/2012 - 11/2002
4	Amyloidogenic ProteinsIBA 01/2012 - 01/2004
4	Advanced Glycation End ProductsIBA 01/2012 - 05/2002
4	Peptide Hydrolases (Proteases)FDA Link 08/2010 - 07/2002
4	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 06/2008 - 03/2003
3	Trace Elements (Biometals)IBA 03/2024 - 07/2018
3	CalciumIBA 03/2024 - 07/2018
3	Coloring Agents (Dyes)IBA 03/2024 - 01/2007
3	VaccinesIBA 01/2023 - 07/2017
3	aducanumabIBA 01/2023 - 01/2022
3	ParaffinIBA 12/2020 - 07/2010
3	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2018 - 01/2006
3	Leuprolide (Lupron)FDA LinkGeneric 01/2018 - 04/2006
3	SugarsIBA 12/2017 - 01/2005
3	Transcription Factors (Transcription Factor)IBA 09/2017 - 10/2009
3	AutoantibodiesIBA 04/2016 - 02/2010
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015 - 09/2005
3	Mitochondrial DNA (mtDNA)IBA 06/2013 - 03/2003
3	NucleosidesIBA 03/2012 - 11/2002
3	Memantine (Namenda)FDA Link 02/2010 - 09/2005
3	PresenilinsIBA 01/2010 - 10/2005
3	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2009 - 03/2003

Therapy/Procedure

39	Therapeutics 03/2024 - 04/2002
6	Immunotherapy 08/2023 - 09/2003
4	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2018 - 08/2004
3	Synchrotrons 03/2024 - 07/2018
3	Lasers (Laser) 02/2018 - 03/2016