Caroline Ospelt Selected Research

Enzymes

2/2016	The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.
5/2010	Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.
7/2004	Time course of coagulation parameters, cytokines and adhesion molecules in Plasmodium falciparum malaria.

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Caroline Ospelt Research Topics

Disease

38	Rheumatoid Arthritis 12/2023 - 10/2005
11	Inflammation (Inflammations) 10/2023 - 10/2005
10	Arthritis (Polyarthritis) 01/2023 - 12/2008
6	Necrosis 01/2022 - 07/2004
5	Osteoarthritis 12/2023 - 12/2008
4	Rheumatic Diseases (Rheumatism) 12/2023 - 01/2007
4	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 12/2009
3	Disease Progression 12/2023 - 05/2007
2	Pain (Aches) 12/2023 - 01/2016
2	Axial Spondyloarthritis 12/2023 - 01/2023
2	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2023 - 11/2016
2	Hypoxia (Hypoxemia) 10/2023 - 06/2012
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 05/2011
2	Neoplasms (Cancer) 01/2016 - 01/2005
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 05/2012 - 02/2009
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2023
1	Vasculitis (Vasculitides) 12/2023
1	Communicable Diseases (Infectious Diseases) 12/2023
1	Vascular Diseases (Vascular Disease) 12/2023
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2023
1	Starvation 12/2019
1	Arthralgia (Joint Pain) 12/2019
1	Intervertebral Disc Degeneration 01/2016
1	Genetic Predisposition to Disease (Genetic Predisposition) 08/2010
1	Experimental Arthritis 05/2010

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 11/2023 - 05/2010
8	MicroRNAs (MicroRNA)IBA 12/2023 - 05/2010
6	CytokinesIBA 12/2023 - 07/2004
6	Toll-Like Receptors (Toll-Like Receptor)IBA 02/2016 - 12/2008
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 07/2004
4	LigandsIBA 02/2016 - 12/2008
3	Biomarkers (Surrogate Marker)IBA 12/2023 - 10/2014
3	GSK1210151AIBA 01/2023 - 02/2016
3	Interleukin-6 (Interleukin 6)IBA 11/2022 - 07/2004
3	AntibodiesIBA 01/2022 - 08/2015
3	AntigensIBA 07/2017 - 05/2010
3	EnzymesIBA 02/2016 - 07/2004
3	InterleukinsIBA 02/2016 - 07/2004
2	acetyl 4-aminosalicylic acidIBA 12/2019 - 07/2017
2	AutoantibodiesIBA 01/2019 - 11/2014
2	AutoantigensIBA 07/2017 - 05/2011
2	Small Interfering RNA (siRNA)IBA 02/2016 - 10/2011
2	Sirtuin 1IBA 02/2016 - 10/2011
2	Pattern Recognition ReceptorsIBA 05/2012 - 02/2009
2	NucleotidesIBA 05/2012 - 02/2009
2	Matrix Metalloproteinases (MMPs)IBA 02/2011 - 01/2007
1	Interleukin-23 (Interleukin 23)IBA 12/2023
1	ChromatinIBA 12/2023
1	Long Noncoding RNAIBA 12/2023
1	S100 Calcium-Binding Protein A4IBA 12/2023
1	Calcium-Binding ProteinsIBA 12/2023
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 10/2023
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2023
1	Uric Acid (Urate)IBA 01/2023
1	Tumor Necrosis Factor InhibitorsIBA 01/2023
1	ZymosanIBA 01/2023
1	ArginaseIBA 01/2022
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Small Cytoplasmic RNAIBA 01/2022
1	Histones (Histone)IBA 01/2021
1	Lysine (L-Lysine)FDA Link 01/2021
1	Nicotine FDA Link 01/2020
1	ChemokinesIBA 12/2019
1	Peptides (Polypeptides)IBA 12/2019
1	Interleukin-8 (Interleukin 8)IBA 12/2019
1	VimentinIBA 07/2017
1	Anti-Citrullinated Protein AntibodiesIBA 07/2017
1	Monoclonal AntibodiesIBA 11/2016
1	interleukin 20 (IL-20)IBA 11/2016
1	Histone Deacetylase 6IBA 09/2016
1	ATPases Associated with Diverse Cellular ActivitiesIBA 09/2016
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 02/2016
1	Histone Deacetylases (Histone Deacetylase)IBA 02/2016
1	C-Reactive ProteinIBA 02/2016
1	LipopolysaccharidesIBA 02/2016
1	gallocatechol (epigallocatechin)IBA 01/2016
1	Untranslated RNA (Noncoding RNA)IBA 01/2016
1	PolyphenolsIBA 01/2016
1	HMGB1 Protein (HMG1)IBA 09/2014
1	SmokeIBA 07/2014
1	Proteasome InhibitorsIBA 01/2014
1	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 01/2014
1	ThapsigarginIBA 01/2014
1	FibrinIBA 08/2013
1	Azacitidine (5 Azacytidine)FDA Link 06/2012
1	pristane (pristan)IBA 05/2011
1	hnRNP A2IBA 05/2011
1	Nucleic AcidsIBA 05/2011
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 05/2011
1	AcetyltransferasesIBA 08/2010
1	SirtuinsIBA 05/2010
1	Matrix Metalloproteinase 13IBA 05/2010
1	Serine Proteases (Serine Protease)IBA 05/2010
1	tocilizumab (atlizumab)FDA Link 12/2009

Therapy/Procedure

7	Therapeutics 12/2023 - 07/2004
1	Precision Medicine 12/2023
1	Injections 01/2023
1	Immunomodulation 08/2010
1	Biological Therapy 12/2009