Bernhard Nieswandt Selected Research

Vascular System Injuries

4/2019	Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.
1/2018	GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice.
7/2015	Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.
11/2012	CLP36 is a negative regulator of glycoprotein VI signaling in platelets.
10/2010	Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
3/2009	Rac1 is essential for phospholipase C-gamma2 activation in platelets.
3/2008	Cell adhesion mechanisms in platelets.
12/2007	Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
7/2003	Platelet-collagen interaction: is GPVI the central receptor?
1/2003	A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo.

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Bernhard Nieswandt Research Topics

Disease

94	Thrombosis (Thrombus) 05/2024 - 06/2002
36	Inflammation (Inflammations) 01/2024 - 02/2006
36	Stroke (Strokes) 08/2022 - 03/2006
22	Hemorrhage 01/2023 - 03/2003
19	Ischemic Stroke 01/2023 - 06/2005
14	Infarction (Infarctions) 01/2023 - 05/2007
10	Myocardial Infarction 01/2023 - 06/2005
10	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/2022 - 05/2007
10	Thrombocytopenia (Thrombopenia) 01/2022 - 03/2003
10	Vascular System Injuries 04/2019 - 01/2003
9	Neoplasms (Cancer) 03/2024 - 02/2010
8	Brain Ischemia (Cerebral Ischemia) 05/2014 - 03/2006
6	Reperfusion Injury 01/2021 - 04/2007
6	Atherosclerosis 01/2017 - 06/2009
5	Ischemia 11/2019 - 10/2012
5	Brain Infarction 09/2013 - 04/2008
4	Atherosclerotic Plaque (Atheroma) 01/2024 - 06/2005
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2023 - 05/2015
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 09/2021 - 02/2010
4	Cerebral Infarction 02/2021 - 05/2007
4	Neoplasm Metastasis (Metastasis) 01/2020 - 02/2010
4	Pulmonary Embolism 04/2015 - 07/2006
3	Sepsis (Septicemia) 03/2024 - 01/2021
3	Pneumonia (Pneumonitis) 03/2024 - 12/2009
3	Neuroinflammatory Diseases 09/2021 - 01/2016
3	Rupture 01/2017 - 06/2005
3	Cardiovascular Diseases (Cardiovascular Disease) 12/2005 - 11/2004
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 05/2024 - 02/2023
2	Fibrosis (Cirrhosis) 07/2023 - 01/2023
2	COVID-19 02/2023 - 01/2023
2	Virus Diseases (Viral Diseases) 01/2023 - 07/2003
2	Infections 04/2021 - 05/2014

Drug/Important Bio-Agent (IBA)

37	Glycoproteins (Glycoprotein)IBA 10/2023 - 04/2003
33	CollagenIBA 03/2022 - 01/2003
18	IntegrinsIBA 12/2023 - 12/2003
16	Proteins (Proteins, Gene)FDA Link 05/2024 - 02/2010
14	Factor XII (Hageman Factor)IBA 11/2021 - 07/2005
12	Collagen ReceptorsIBA 12/2022 - 11/2004
11	Thrombin FDA Link 04/2023 - 07/2004
11	FibrinIBA 04/2023 - 06/2005
11	Hemostatics (Antihemorrhagics)IBA 12/2019 - 07/2003
8	AntibodiesIBA 01/2020 - 03/2003
8	von Willebrand FactorIBA 01/2019 - 04/2009
7	platelet membrane glycoprotein VIIBA 05/2024 - 06/2005
7	LigandsIBA 01/2024 - 12/2007
7	Platelet Membrane GlycoproteinsIBA 08/2022 - 07/2004
6	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 12/2005
6	Peptide Hydrolases (Proteases)FDA Link 12/2021 - 02/2006
6	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 09/2021 - 11/2003
6	Immunoglobulin G (IgG)IBA 02/2021 - 03/2003
6	AntigensIBA 02/2021 - 03/2003
6	CalciumIBA 11/2019 - 07/2008
5	EnzymesIBA 01/2024 - 01/2012
5	Thromboplastin (Tissue Factor)IBA 01/2023 - 06/2005
5	CytokinesIBA 01/2021 - 12/2009
4	LipidsIBA 01/2024 - 06/2005
4	Therapeutic UsesIBA 08/2022 - 06/2015
4	Adenosine Diphosphate (ADP)IBA 07/2022 - 04/2003
4	C-Type Lectins (C-Type Lectin)IBA 04/2021 - 05/2013
4	Immunoglobulin Fab FragmentsIBA 11/2017 - 05/2007
4	Monoclonal AntibodiesIBA 04/2016 - 08/2006
4	Phospholipases (Phospholipase)IBA 01/2016 - 12/2005
4	von Willebrand factor receptor (VWF receptor)IBA 01/2014 - 12/2005
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2023 - 10/2005
3	Calcium Channels (Calcium Channel)IBA 08/2022 - 04/2016
3	Fibronectins (Fibronectin)IBA 03/2022 - 09/2010
3	Biomarkers (Surrogate Marker)IBA 02/2022 - 01/2014
3	Clopidogrel (Plavix)FDA Link 01/2022 - 01/2009
3	adhesion receptorIBA 02/2021 - 04/2009
3	Fibrinogen (Factor I)FDA Link 01/2019 - 01/2012
3	Antigen-Antibody Complex (Immune Complex)IBA 01/2018 - 01/2014
3	Apolipoproteins E (ApoE)IBA 01/2017 - 09/2010
3	triphenyltetrazoliumIBA 04/2016 - 05/2007
3	PhosphatidylserinesIBA 02/2016 - 07/2004
3	1-dodecylpyridoxal (PLD)IBA 01/2016 - 11/2012
3	Epinephrine (Adrenaline)FDA LinkGeneric 04/2015 - 07/2005
3	phospholipase D1IBA 08/2014 - 01/2010
3	Protein Isoforms (Isoforms)IBA 09/2013 - 03/2007
3	CoagulantsIBA 07/2013 - 09/2011
3	P-SelectinIBA 02/2010 - 07/2006
3	Integrin alpha2beta1IBA 11/2007 - 04/2003
3	Platelet Glycoprotein GPIIb-IIIa ComplexIBA 07/2006 - 06/2002
2	Thrombopoietin (c-mpl Ligand)IBA 03/2024 - 05/2015
2	Semaphorins (Semaphorin)IBA 03/2024 - 11/2020
2	Insulin (Novolin)FDA Link 11/2023 - 01/2016
2	LipopolysaccharidesIBA 10/2023 - 04/2015
2	Actins (F Actin)IBA 12/2022 - 01/2020
2	Laminin (Merosin)IBA 03/2022 - 01/2019
2	ChemokinesIBA 01/2022 - 01/2020
2	GTP-Binding Proteins (G-Protein)IBA 01/2022 - 03/2009
2	Syk KinaseIBA 12/2021 - 01/2021
2	InterleukinsIBA 01/2021 - 05/2014
2	AnticoagulantsIBA 01/2021 - 11/2008
2	Carrier Proteins (Binding Protein)IBA 01/2020 - 10/2012
2	Glucose (Dextrose)FDA LinkGeneric 11/2019 - 01/2016
2	Serotonin (5 Hydroxytryptamine)IBA 01/2018 - 01/2016

Therapy/Procedure

14	Therapeutics 05/2024 - 11/2004
5	Thrombectomy 01/2022 - 10/2018
3	Ligation 01/2023 - 04/2016
2	Extracorporeal Membrane Oxygenation 05/2024 - 01/2016