Dale G Nagle Selected Research

Proteins (Proteins, Gene)

9/2011	Mitochondrial respiration inhibitors suppress protein translation and hypoxic signaling via the hyperphosphorylation and inactivation of translation initiation factor eIF2α and elongation factor eEF2.
5/2010	The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.
12/2009	The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.
8/2005	Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1.
6/2005	Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

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Dale G Nagle Research Topics

Disease

29	Neoplasms (Cancer) 01/2024 - 05/2004
29	Hypoxia (Hypoxemia) 11/2018 - 05/2004
19	Breast Neoplasms (Breast Cancer) 11/2018 - 12/2004
2	Triple Negative Breast Neoplasms 01/2024 - 01/2021
2	Melanoma (Melanoma, Malignant) 01/2024 - 01/2021
2	Inflammation (Inflammations) 01/2017 - 06/2006
2	Psoriasis (Pustulosis Palmaris et Plantaris) 06/2006 - 08/2005
2	Mycoses (Diseases, Fungus) 04/2006 - 09/2003
1	Neoplasm Metastasis (Metastasis) 01/2024
1	Carcinoma (Carcinomatosis) 01/2024
1	Stomach Neoplasms (Stomach Cancer) 05/2023
1	Squamous Cell Carcinoma of Head and Neck 11/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Asthma (Bronchial Asthma) 01/2017
1	Eosinophilia 01/2017
1	Respiratory Hypersensitivity 01/2017
1	Hypersensitivity (Allergy) 12/2012
1	Prostatic Neoplasms (Prostate Cancer) 03/2008
1	Weight Loss (Weight Reduction) 09/2006

Drug/Important Bio-Agent (IBA)

14	Transcription Factors (Transcription Factor)IBA 01/2017 - 05/2004
9	LipidsIBA 01/2024 - 12/2006
7	Chelating AgentsIBA 09/2012 - 05/2004
7	IronIBA 09/2012 - 05/2004
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015 - 12/2004
5	Peptides (Polypeptides)IBA 01/2024 - 01/2021
5	Antineoplastic Agents (Antineoplastics)IBA 09/2012 - 05/2004
5	Proteins (Proteins, Gene)FDA Link 09/2011 - 06/2005
4	Oxygen (Dioxygen)IBA 06/2013 - 12/2004
2	Adenosine Triphosphate (ATP)IBA 01/2024 - 12/2012
2	AntibodiesIBA 01/2022 - 01/2021
2	MicroRNAs (MicroRNA)IBA 09/2021 - 01/2020
2	SesterterpenesIBA 08/2013 - 11/2007
2	CoumarinsIBA 02/2011 - 11/2010
2	Terpenes (Terpenoids)IBA 11/2008 - 06/2005
2	laurenditerpenolIBA 12/2007 - 12/2004
2	TeaIBA 09/2006 - 12/2004
2	manassantin BIBA 08/2005 - 05/2004
1	MicellesIBA 01/2024
1	Adenosine (Adenocard)FDA LinkGeneric 01/2024
1	AntigensIBA 01/2024
1	ciforadenantIBA 01/2024
1	Proteolysis Targeting ChimeraIBA 05/2023
1	CrizotinibIBA 05/2023
1	snake venom protein C activatorIBA 11/2022
1	PolymersIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 09/2021
1	Circular RNAIBA 09/2021
1	Peptide Hydrolases (Proteases)FDA Link 01/2021
1	Wasp Venoms (Venom, Wasp)IBA 01/2021
1	Histone Deacetylases (Histone Deacetylase)IBA 11/2018
1	Histone Deacetylase InhibitorsIBA 11/2018
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2018
1	STA 9090IBA 01/2018
1	tanespimycin (17AAG)IBA 01/2018
1	Peroxidase (Myeloperoxidase)IBA 01/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017
1	Interleukin-5 (Interleukin 5)IBA 01/2017
1	Interleukin-13IBA 01/2017
1	sampangineIBA 12/2015
1	kalkitoxinIBA 03/2015
1	Cytostatic AgentsIBA 03/2015
1	thorectidaeolide AIBA 08/2013
1	4-acetoxythorectidaeolide AIBA 08/2013
1	luffariellolideIBA 08/2013
1	PoisonsIBA 04/2013
1	auraptenIBA 04/2013
1	RotenoneIBA 12/2012
1	Lactic Acid (Lactate)FDA LinkGeneric 12/2012
1	Glucose (Dextrose)FDA LinkGeneric 12/2012
1	thyrsiferolIBA 06/2011
1	coumarinIBA 11/2010
1	Mammea E-BB compoundIBA 11/2010
1	mycothiazoleIBA 08/2010
1	AcetogeninsIBA 05/2010
1	annonacinIBA 05/2010
1	Complex MixturesIBA 05/2010
1	caulerpinIBA 12/2009
1	Conditioned Culture MediaIBA 12/2009
1	furospongolideIBA 11/2008
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 11/2008
1	matrigelIBA 03/2008
1	CarbamatesIBA 03/2008
1	latrunculin A (LAT-A)IBA 03/2008
1	naphthaleneIBA 11/2007
1	LuciferasesIBA 09/2007
1	PeroxidesIBA 01/2007
1	TriterpenesIBA 12/2006
1	AntioxidantsIBA 09/2006
1	Interleukin-15 (Interleukin 15)IBA 06/2006
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 06/2006
1	carbazoleIBA 06/2006
1	Coal Tar (Estar)IBA 06/2006
1	AzolesIBA 04/2006
1	psammaplin AIBA 04/2006
1	PPAR gammaIBA 04/2006

Therapy/Procedure

4	Therapeutics 01/2017 - 08/2005
3	Immunotherapy 01/2024 - 01/2021
2	Drug Therapy (Chemotherapy) 01/2021 - 07/2004
2	Chemoprevention 09/2006 - 12/2004
1	Complementary Therapies (Alternative Medicine) 05/2010