Shigeo Murata Selected Research

Infections

1/2019	Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii.
1/2019	Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
12/2009	Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.
3/2008	Critical contribution of immunoproteasomes in the induction of protective immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein.
1/2007	Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis.
4/2006	The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1.

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Shigeo Murata Research Topics

Disease

9	Neoplasms (Cancer) 07/2020 - 05/2004
6	Infections 01/2019 - 04/2006
3	Obesity 01/2023 - 03/2012
3	Insulin Resistance 01/2023 - 02/2007
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 06/2006
2	Inflammation (Inflammations) 06/2015 - 09/2011
2	Starvation 06/2006 - 05/2005
2	Melanoma (Melanoma, Malignant) 08/2004 - 05/2004
1	Cognitive Dysfunction 03/2024
1	Muscular Atrophy (Muscle Atrophy) 01/2023
1	Retinoblastoma (Glioblastoma, Retinal) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Malaria 01/2019
1	Hyperlactatemia 01/2019
1	Parasitemia 01/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018
1	Carcinoma (Carcinomatosis) 08/2017
1	Fallopian Tube Neoplasms 08/2017
1	Carcinoma in Situ 08/2017
1	Ovarian Neoplasms (Ovarian Cancer) 08/2017
1	Long Qt Syndrome 2 12/2013
1	Necrosis 09/2013
1	Hepatocellular Carcinoma (Hepatoma) 03/2013
1	Urinary Bladder Neoplasms (Bladder Cancer) 08/2012
1	Fever (Fevers) 09/2011
1	X-Linked Bulbo-Spinal Atrophy 03/2009
1	Hepatitis C 02/2007
1	Fatty Liver 01/2007
1	Lewis Lung Carcinoma 05/2006
1	Experimental Melanoma 08/2004

Drug/Important Bio-Agent (IBA)

16	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2024 - 05/2004
13	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2004
7	UbiquitinIBA 01/2020 - 06/2006
3	DNA (Deoxyribonucleic Acid)IBA 08/2012 - 08/2004
3	AntigensIBA 12/2009 - 05/2004
2	Proteasome InhibitorsIBA 07/2020 - 08/2017
2	RA190IBA 08/2017 - 01/2017
2	Bortezomib (Velcade)FDA Link 08/2017 - 03/2013
2	Messenger RNA (mRNA)IBA 08/2017 - 12/2009
2	ATP dependent 26S protease (26S proteasome)IBA 03/2013 - 02/2009
2	Ki antigenIBA 02/2007 - 01/2007
2	EpitopesIBA 05/2006 - 08/2004
1	Retinoblastoma ProteinIBA 01/2020
1	Peptide Hydrolases (Proteases)FDA Link 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2020
1	CytokinesIBA 01/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2019
1	Interleukin-10 (Interleukin 10)IBA 01/2019
1	Type III Secretion SystemsIBA 01/2019
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	PiperidonesIBA 01/2017
1	Deubiquitinating EnzymesIBA 01/2017
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 09/2013
1	Phosphotransferases (Kinase)IBA 03/2013
1	DNA VaccinesIBA 08/2012
1	VaccinesIBA 08/2012
1	Aquaporins (Water Channels)IBA 08/2012
1	Chymotrypsin FDA Link 03/2012
1	Interleukin-6 (Interleukin 6)IBA 09/2011
1	Androgen Receptors (Androgen Receptor)IBA 03/2009
1	Insulin (Novolin)FDA Link 02/2007
1	Glucose (Dextrose)FDA LinkGeneric 02/2007
1	Amino Acids FDA Link 05/2005
1	Monophenol Monooxygenase (Tyrosinase)IBA 08/2004
1	Green Fluorescent ProteinsIBA 08/2004
1	Interferon-gamma (Interferon, gamma)IBA 05/2004
1	Formaldehyde (Formol)FDA Link 05/2004
1	Neoplasm Antigens (Tumor Antigens)IBA 05/2004
1	Interleukin-12 (IL 12)IBA 05/2004

Therapy/Procedure

3	Therapeutics 07/2020 - 08/2012
1	Immunotherapy 05/2004