Brendon J Monahan Selected Research

Therapeutics

10/2023	Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
11/2019	Fragment screening for a protein-protein interaction inhibitor to WDR5.

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Brendon J Monahan Research Topics

Disease

6	Neoplasms (Cancer) 10/2023 - 12/2011
2	Starvation 02/2006 - 02/2002
1	Breast Neoplasms (Breast Cancer) 10/2023
1	Carcinogenesis 01/2022
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Bites and Stings (Sting) 09/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Lymphoma (Lymphomas) 01/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2017
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2011
1	Leukemia 12/2011

Drug/Important Bio-Agent (IBA)

2	Lysine AcetyltransferasesIBA 10/2023 - 01/2020
2	Histone Acetyltransferases (Histone Acetyltransferase)IBA 10/2023 - 12/2011
2	Histones (Histone)IBA 10/2023 - 01/2022
2	Proteins (Proteins, Gene)FDA Link 10/2017 - 12/2011
2	NitrogenIBA 02/2006 - 02/2002
2	Ammonium CompoundsIBA 02/2006 - 02/2002
2	adenosine 5'-(O-methylphosphate) (MEPA)IBA 02/2006 - 02/2002
1	RNA Polymerase II (RNA Polymerase B)IBA 10/2023
1	Estrogens (Estrogen)FDA Link 10/2023
1	InterferonsIBA 09/2020
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 09/2020
1	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 09/2020
1	ChromatinIBA 11/2019
1	2-(phenylsulfonyl)hydrazide 4-fluoro-5-methyl- (1,1'-Biphenyl)-3-carboxylic acidIBA 01/2018
1	2- Fluoro- N'- (3- fluoro- 5- (pyridin- 2- yl)benzoyl)benzenesulfonohydrazideIBA 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2017
1	Membrane Transport Proteins (Biological Pump)IBA 02/2006
1	2-methylphenyl cinnamateIBA 02/2006

Therapy/Procedure

2	Therapeutics 10/2023 - 11/2019