Michael S Middleton Selected Research

Non-alcoholic Fatty Liver Disease

10/2023	Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium.
1/2023	MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.
1/2023	Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis.
11/2021	Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis.
9/2020	Prospective comparison of longitudinal change in hepatic proton density fat fraction (PDFF) estimated by magnitude-based MRI (MRI-M) and complex-based MRI (MRI-C).
1/2020	Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial.
1/2020	The relationship between liver triglyceride composition and proton density fat fraction as assessed by 1 H MRS.
1/2019	Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib.
1/2019	Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.
1/2019	Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial.

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Michael S Middleton Research Topics

Disease

25	Non-alcoholic Fatty Liver Disease 10/2023 - 08/2011
11	Fibrosis (Cirrhosis) 01/2023 - 01/2015
5	Liver Diseases (Liver Disease) 10/2023 - 12/2009
4	Fatty Liver 10/2023 - 07/2009
2	Inflammation (Inflammations) 01/2023 - 11/2021
2	Obesity 01/2020 - 01/2019
2	Rupture 05/2014 - 02/2002
2	Breast Neoplasms (Breast Cancer) 05/2014 - 09/2006
1	Weight Loss (Weight Reduction) 09/2020
1	Pruritus (Itching) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Alcoholic Fatty Liver 01/2019
1	Overweight 10/2015
1	Infections 01/2015
1	Hypersensitivity (Allergy) 11/2014
1	Wolman Disease (Wolman's Disease) 11/2014
1	Nephrogenic Fibrosing Dermopathy 12/2009
1	Renal Insufficiency (Renal Failure) 12/2009
1	Congenital Abnormalities (Deformity) 02/2002
1	Confusion (Bewilderment) 02/2002

Drug/Important Bio-Agent (IBA)

18	Protons (Proton)IBA 01/2023 - 06/2014
8	Biomarkers (Surrogate Marker)IBA 10/2023 - 06/2015
4	SteamIBA 01/2020 - 07/2009
3	Triglycerides (Triacylglycerol)IBA 01/2020 - 11/2014
3	Alanine Transaminase (SGPT)IBA 01/2019 - 04/2010
2	nasIBA 01/2023 - 01/2019
2	IronIBA 01/2019 - 01/2015
2	firsocostatIBA 12/2018 - 11/2018
1	Pyridinolcarbamate (P23)IBA 01/2022
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2020
1	cilofexorIBA 01/2020
1	Bile Acids and Salts (Bile Acids)IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2019
1	selonsertibIBA 01/2019
1	SugarsIBA 01/2019
1	Acetyl-CoA CarboxylaseIBA 12/2018
1	Tissue Inhibitor of Metalloproteinase-1IBA 11/2018
1	Cysteamine (Mercaptamine)FDA Link 01/2018
1	gadolinium ethoxybenzyl DTPA FDA Link 01/2017
1	ferumoxides (Feridex)FDA Link 01/2015
1	CollagenIBA 01/2015
1	Gadolinium DTPA (Magnevist)FDA Link 01/2015
1	OxidesIBA 01/2015
1	Transaminases (Aminotransferases)IBA 11/2014
1	Cholesterol Esters (Cholesteryl Esters)IBA 11/2014
1	EnzymesIBA 11/2014
1	Sebelipase alfaIBA 11/2014
1	LipidsIBA 11/2014
1	TESIBA 08/2011
1	EmulsionsIBA 08/2011
1	Contrast MediaIBA 12/2009
1	gadodiamide (Omniscan)FDA Link 12/2009
1	GadoliniumIBA 12/2009
1	Capsules (Microcapsules)IBA 02/2002
1	SiliconesIBA 02/2002

Therapy/Procedure

1	Aftercare (After-Treatment) 01/2018
1	Intravenous Administration 01/2015
1	Breast Implants (Breast Implant) 05/2014
1	Transplantation 12/2009
1	Mastectomy (Mammectomy) 09/2006
1	Segmental Mastectomy (Lumpectomy) 09/2006