Hiroshi Maruta Selected Research

artepillin C

12/2017	From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
5/2017	1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.
1/2016	Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture.
3/2009	Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.

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Hiroshi Maruta Research Topics

Disease

21	Neoplasms (Cancer) 08/2021 - 07/2002
6	Neurofibromatoses (Neurofibromatosis) 05/2014 - 04/2005
3	Pancreatic Neoplasms (Pancreatic Cancer) 11/2019 - 01/2007
3	Pain (Aches) 11/2019 - 01/2017
3	AIDS-Related Complex (ARC) 12/2017 - 03/2009
3	Lung Neoplasms (Lung Cancer) 05/2017 - 08/2015
3	Melanoma (Melanoma, Malignant) 01/2017 - 01/2016
3	Prostatic Neoplasms (Prostate Cancer) 03/2009 - 04/2005
2	Alzheimer Disease (Alzheimer's Disease) 05/2017 - 05/2014
2	Type 2 Diabetes Mellitus (MODY) 05/2017 - 05/2014
2	Sarcoma (Soft Tissue Sarcoma) 01/2007 - 01/2004
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 08/2021
1	COVID-19 06/2020
1	Virus Diseases (Viral Diseases) 06/2020
1	Inflammation (Inflammations) 06/2020
1	Human Influenza (Influenza) 06/2020
1	Malaria 06/2020
1	Rabies (Hydrophobia) 06/2020
1	Infections 01/2020
1	Neoplasm Metastasis (Metastasis) 11/2019
1	Hypertension (High Blood Pressure) 05/2017
1	Xeroderma Pigmentosum (Kaposi's Disease) 01/2017
1	Alopecia (Baldness) 01/2016
1	Arthritis (Polyarthritis) 05/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 05/2014
1	Asthma (Bronchial Asthma) 05/2014
1	Autistic Disorder (Autism) 05/2014
1	Bacterial Infections (Bacterial Infection) 05/2014
1	Epilepsy (Aura) 05/2014
1	Learning Disabilities (Learning Disability) 05/2014
1	Schizophrenia (Dementia Praecox) 05/2014
1	Tuberous Sclerosis (Bourneville's Disease) 05/2014
1	Breast Neoplasms (Breast Cancer) 01/2007
1	Neurofibrosarcoma (MPNST) 04/2005
1	Neurofibroma 04/2005
1	Neurofibromatosis 2 (Neurofibromatosis Type II) 01/2004
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2004

Drug/Important Bio-Agent (IBA)

16	Phosphotransferases (Kinase)IBA 06/2020 - 07/2002
6	KetorolacIBA 06/2020 - 01/2017
6	Propolis (Bee Bread)IBA 06/2020 - 03/2009
5	EstersIBA 11/2019 - 01/2017
4	artepillin CIBA 12/2017 - 03/2009
4	Pharmaceutical PreparationsIBA 05/2017 - 04/2005
4	romidepsin (FK228)FDA Link 01/2007 - 04/2005
3	Adenosine Triphosphate (ATP)IBA 01/2017 - 07/2002
2	Gemcitabine FDA Link 11/2019 - 01/2007
2	caffeic acidIBA 12/2017 - 05/2017
2	caffeic acid phenethyl esterIBA 08/2015 - 03/2009
2	Estrogens (Estrogen)FDA Link 01/2007 - 09/2005
2	AG-879IBA 01/2007 - 01/2004
2	src-Family KinasesIBA 01/2007 - 01/2004
2	Cyclin D1IBA 03/2006 - 09/2005
2	Histone Deacetylase InhibitorsIBA 09/2005 - 04/2005
2	Histone Deacetylases (Histone Deacetylase)IBA 09/2005 - 04/2005
1	Imatinib Mesylate (Gleevec)FDA Link 08/2021
1	VaccinesIBA 06/2020
1	ciclesonide FDA Link 06/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2020
1	Chloroquine (Aralen)FDA LinkGeneric 06/2020
1	MelatoninIBA 06/2020
1	LuciferasesIBA 11/2019
1	frondoside AIBA 05/2017
1	SaponinsIBA 05/2017
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2017
1	Ketorolac Tromethamine (Acular)FDA LinkGeneric 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Monophenol Monooxygenase (Tyrosinase)IBA 01/2017
1	Melanins (Melanin)IBA 01/2017
1	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)IBA 01/2017
1	Hormones (Hormone)IBA 01/2017
1	Melanocyte-Stimulating Hormones (MSH)IBA 01/2017
1	Cisplatin (Platino)FDA LinkGeneric 01/2017
1	5,6-dehydrokawainIBA 01/2016
1	CurcuminIBA 01/2016
1	MimosineIBA 01/2016
1	hispidinIBA 01/2016
1	cucurbitacin IIBA 01/2016
1	cdc42 GTP-Binding ProteinIBA 05/2014
1	ras ProteinsIBA 01/2007
1	kigamicin DIBA 01/2007
1	GL-2003IBA 01/2007
1	Codon (Codons)IBA 01/2007
1	Estrogen ReceptorsIBA 09/2005
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 09/2005
1	Estrogen AntagonistsIBA 09/2005
1	Tamoxifen FDA LinkGeneric 09/2005
1	GelsolinIBA 04/2005
1	3,9-bis((ethylthio)methyl)-K-252aIBA 01/2004
1	Neurofibromin 2 (Merlin)IBA 01/2004
1	SugarsIBA 07/2002
1	staurosporine aglycone (K252a)IBA 07/2002
1	StaurosporineIBA 07/2002

Therapy/Procedure

9	Therapeutics 06/2020 - 01/2004
1	Neoadjuvant Therapy 08/2021
1	Mechanical Ventilators (Ventilator) 06/2020
1	Drug Therapy (Chemotherapy) 01/2017