Ryan Limbocker Selected Research

Proteins (Proteins, Gene)

2/2024	Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.
2/2023	EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity.
1/2023	Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
1/2021	Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
11/2020	Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers.
1/2020	Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
1/2020	A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
1/2020	Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.

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Ryan Limbocker Research Topics

Disease

11	Alzheimer Disease (Alzheimer's Disease) 02/2024 - 10/2017
6	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2023 - 11/2020
5	Parkinson Disease (Parkinson's Disease) 01/2023 - 01/2017
3	Neuroblastoma 02/2024 - 01/2017
3	Proteostasis Deficiencies 02/2024 - 01/2020
3	Amyloid Plaque 01/2023 - 01/2020
2	Paralysis (Palsy) 01/2018 - 01/2017
1	Synucleinopathies 01/2023
1	Nervous System Diseases (Neurological Disorders) 01/2021

Drug/Important Bio-Agent (IBA)

11	Amyloid (Amyloid Fibrils)IBA 02/2024 - 10/2017
8	Peptides (Polypeptides)IBA 02/2024 - 10/2017
8	Proteins (Proteins, Gene)FDA Link 02/2024 - 01/2020
5	SynucleinsIBA 01/2023 - 01/2017
3	24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA 01/2022 - 01/2018
2	squalamineIBA 01/2022 - 01/2017
1	MetalsIBA 02/2024
1	IonsIBA 02/2024
1	SolventsIBA 02/2023
1	Amyloidogenic ProteinsIBA 01/2023
1	Intrinsically Disordered ProteinsIBA 01/2018
1	LipidsIBA 01/2017