Hetian Lei Selected Research

Proliferative Vitreoretinopathy

8/2023	Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells.
1/2023	NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells.
10/2021	Chalcomoracin prevents vitreous-induced activation of AKT and migration of retinal pigment epithelial cells.
11/2020	Exosomes mediate an epithelial-mesenchymal transition cascade in retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy.
1/2020	PDGFRβ plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes.
10/2019	Phosphoinositide 3-kinase δ inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.
10/2017	Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy.
1/2016	Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases.
1/2014	A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.
2/2013	SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models.

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Hetian Lei Research Topics

Disease

17	Proliferative Vitreoretinopathy 08/2023 - 05/2007
10	Neoplasms (Cancer) 11/2023 - 10/2002
7	Retinal Detachment (Retinal Detachments) 08/2023 - 05/2007
7	Epiretinal Membrane (Epiretinal Membranes) 08/2023 - 03/2009
5	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2023 - 01/2017
3	Eye Diseases (Eye Disease) 10/2021 - 10/2019
2	Macular Degeneration (Age-Related Maculopathy) 01/2021 - 01/2017
1	Corneal Neovascularization 04/2024
1	Infections 01/2023
1	Myocardial Infarction 01/2023
1	Acute Coronary Syndrome 01/2023
1	Stable Angina 01/2023
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2023
1	Hepatocellular Carcinoma (Hepatoma) 01/2022
1	Hypoxia (Hypoxemia) 01/2022
1	Carcinogenesis 01/2022
1	Choroidal Neovascularization 01/2017
1	Fibrosis (Cirrhosis) 02/2013
1	Gliosis 02/2013
1	Medulloblastoma 01/2011
1	Brain Neoplasms (Brain Tumor) 01/2011
1	Prostatic Neoplasms (Prostate Cancer) 05/2010
1	Disease Progression 03/2009
1	Retinal Diseases 03/2009
1	Diabetes Mellitus 03/2007
1	Neoplasm Metastasis (Metastasis) 08/2004
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 08/2004
1	Breast Neoplasms (Breast Cancer) 08/2004
1	Diabetes Complications 04/2004

Drug/Important Bio-Agent (IBA)

8	Retinaldehyde (Retinal)IBA 01/2023 - 01/2008
7	Retinal Pigments (Pigments, Visual)IBA 08/2023 - 10/2017
6	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2014 - 03/2009
5	Protein Isoforms (Isoforms)IBA 11/2023 - 05/2007
5	Platelet-Derived Growth FactorIBA 01/2020 - 03/2009
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2024 - 10/2002
3	platelet-derived growth factor C (PDGF-C)IBA 03/2009 - 05/2007
2	idelalisibIBA 12/2022 - 01/2020
2	CollagenIBA 12/2022 - 09/2012
2	Phosphotransferases (Kinase)IBA 01/2021 - 10/2019
2	EndonucleasesIBA 10/2017 - 01/2017
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2017 - 10/2002
2	LigandsIBA 05/2010 - 03/2009
2	Platelet-Derived Growth Factor alpha ReceptorIBA 05/2010 - 03/2009
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2009 - 03/2009
2	peptide F56IBA 08/2004 - 10/2002
2	Peptides (Polypeptides)IBA 08/2004 - 10/2002
1	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 08/2023
1	Untranslated RNA (Noncoding RNA)IBA 01/2023
1	Indicators and Reagents (Reagents)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	Troponin IIBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	Long Noncoding RNAIBA 01/2023
1	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2022
1	Fibronectins (Fibronectin)IBA 12/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	Interleukin-13 Receptors (Interleukin 13 Receptor)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022
1	tyrosine receptor (receptor, tyrosine)IBA 01/2021
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2021
1	capilliposide BIBA 01/2021
1	platelet-derived growth factor AIBA 01/2020
1	Tumor Suppressor Protein p53IBA 10/2019
1	Cell Adhesion MoleculesIBA 01/2017
1	Netrin-1IBA 01/2017
1	Oxygen (Dioxygen)IBA 01/2017
1	phosphatidylinositol 5-phosphateIBA 01/2016
1	SU9518IBA 02/2013
1	nutlin 3IBA 09/2012
1	Acetylcysteine (Siran)FDA LinkGeneric 07/2010
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2010
1	N-myristoyl-alaninol (D-MA)IBA 03/2009
1	Peptide Hydrolases (Proteases)FDA Link 01/2008
1	Fibrinolysin FDA Link 01/2008
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2007
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 03/2007
1	Glucose (Dextrose)FDA LinkGeneric 03/2007
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 08/2004
1	Membrane Proteins (Integral Membrane Proteins)IBA 04/2004

Therapy/Procedure

4	Vitrectomy 01/2021 - 05/2007
2	Therapeutics 01/2021 - 08/2004
1	Sutures (Suture) 04/2024
1	Percutaneous Coronary Intervention 01/2023
1	Lasers (Laser) 01/2017
1	Intravitreal Injections 07/2010