João Leandro Selected Research

Inborn Errors Metabolism (Inborn Errors of Metabolism)

1/2022	Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
7/2014	Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators.

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João Leandro Research Topics

Disease

6	Phenylketonurias (Phenylketonuria) 01/2021 - 09/2008
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 05/2006
2	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/2022 - 07/2014
2	Brain Diseases (Brain Disorder) 11/2020 - 01/2020
2	Proteostasis Deficiencies 01/2011 - 01/2011
1	Methylmalonic acidemia 01/2023
1	Beta-Hydroxyisobutyryl CoA Deacylase Deficiency 01/2023
1	Propionic Acidemia 01/2023
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2022
1	Eosinophilic Esophagitis 07/2022
1	Communicable Diseases (Infectious Diseases) 03/2021
1	Neoplasms (Cancer) 03/2021
1	Psychomotor Disorders 01/2021
1	Pyridoxine-dependent epilepsy 09/2020
1	Ataxia (Dyssynergia) 01/2020
1	Epilepsy (Aura) 01/2020
1	Intellectual Disability (Idiocy) 01/2020
1	Medium chain acyl CoA dehydrogenase deficiency 12/2016
1	Transthyretin-Related Hereditary Amyloidosis 07/2014

Drug/Important Bio-Agent (IBA)

5	Lysine (L-Lysine)FDA Link 01/2022 - 01/2020
5	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 01/2021 - 09/2008
4	hydralazine 4-anisaldehyde hydrazoneIBA 01/2021 - 09/2008
3	Proteins (Proteins, Gene)FDA Link 07/2014 - 05/2006
2	EnzymesIBA 03/2021 - 01/2011
2	Amino Acids FDA Link 09/2010 - 09/2008
1	3-hydroxyisobutyryl-CoA hydrolaseIBA 01/2023
1	Enoyl-CoA HydrataseIBA 01/2023
1	Isoleucine (L-Isoleucine)FDA Link 01/2023
1	Valine (L-Valine)FDA Link 01/2023
1	Oxidoreductases (Dehydrogenase)IBA 07/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	HydroxylysineIBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2016
1	tafamidisIBA 07/2014
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2011

Therapy/Procedure

1	Therapeutics 01/2011